In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields
In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields
复制标题
DOI：
10.1016/s1090-7807(02)00198-2
复制
发表时间：
2003-05-01
影响因子：
2.2
通讯作者：
Tastevin, G
中科院分区：
文献类型：
--
作者：
Bidinosti, CP;Choukeife, J;Tastevin, G
我们介绍了超极化He-3在人肺中扩散的核磁共振测量，测量的磁场比传统核磁共振扫描仪低得多。这些测量是使用自制的仪器在3mT下对站立的受试者进行的。在活体内可以测量到氧限制的横向松弛(T-2可达15-35 S)。在体内和塑料袋中进行了精确的全局扩散测量；体内的平均表观扩散系数为14.2+/-0.6 mm(2)/S，而袋中(He-3在N-2中稀释)的扩散系数为79.5+/-1 mm(2)/S。高信噪比(类似于200-300)的IDADC标测证实了在极低场下进行高质量肺成像的真正可能性。(C)2003年埃尔塞维尔科学公司(美国)。版权所有。
We present NMR measurements of the diffusion of hyperpolarized He-3 in the human lung performed at fields much lower than those of conventional MRI scanners. The measurements were made on standing subjects using homebuilt apparatus operating at 3 mT. O-2-limited transverse relaxation (T-2 up to 15-35 s) could be measured in vivo. Accurate global diffusion measurements have been performed in vivo and in a plastic bag; the average apparent diffusion coefficient (ADC) in vivo was 14.2 +/- 0.6 mm(2)/s, whereas the diffusion coefficient in the bag (He-3 diluted in N-2) was 79.5 +/- 1 mm(2)/s. ID ADC mapping with high SNR (similar to200-300) demonstrates the real possibility of performing quality lung imaging at extremely low fields. (C) 2003 Elsevier Science (USA). All rights reserved.