GOSSYPOL BINDS TO A HIGH-AFFINITY BINDING-SITE ON HUMAN-SERUM ALBUMIN
GOSSYPOL BINDS TO A HIGH-AFFINITY BINDING-SITE ON HUMAN-SERUM ALBUMIN
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DOI：
10.1016/0014-5793(83)81109-0
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发表时间：
1983-01-01
期刊：
影响因子：
3.5
通讯作者：
VANDERJAGT, DL
中科院分区：
文献类型：
--
作者：
ROYER, RE;VANDERJAGT, DL
三萜棉酚与胆红素竞争人血清白蛋白的高亲和力结合部位。胆红素和棉酚之间的竞争类似于这些配体与来自人类肝脏和胎盘的谷胱甘肽转移酶的结合。在每种情况下，棉酚和胆红素都表现出相似的结合常数。棉酚的结合特性通常与胆红素的结合特性相似。
The triterpene gossypol competes with bilirubin for a high-affinity binding site on human serum albumin. Similar competition between bilirubin and gossypol occurs in the binding of these ligands to the glutathioneS-transferases from human liver and placenta. In each case, gossypol and bilirubin exhibit similar binding constants. The binding properties of gossypol may generally mimic those of bilirubin.