Comparative genomics of 10 new Caenorhabditis species
Comparative genomics of 10 new Caenorhabditis species
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DOI：
10.1002/evl3.110
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发表时间：
2019-04-01
影响因子：
5
通讯作者：
Blaxter, Mark
中科院分区：
文献类型：
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作者：
Stevens, Lewis;Felix, Marie-Anne;Blaxter, Mark
线虫秀丽隐杆线虫（Caesiumhabditis elegans）是了解后生动物生物学的核心。然而，C.秀丽线虫只是数百万种中的一种，只有将其置于丰富的进化背景中，才能充分揭示这一重要模式生物的意义。全球采样工作已经导致发现了50多个假定的物种，其中许多正在等待正式的物种描述。在这里，我们提出了10个新的小杆线虫种的描述。我们还提出了这些新物种中的九个的基因组序列草案，沿着其中一个的转录组组装。我们利用这些全基因组数据来重建小杆线虫的系统发育，并使用这个系统发育树来解剖该属的形态进化。我们揭示了基因组大小的广泛变化，并研究了这种变化背后的分子过程。我们在关键发育途径基因的进化历史中显示出意想不到的复杂性。这些新的物种和相关的基因组资源将是必不可少的，在我们试图了解的进化起源的C。elegans模型
The nematode Caenorhabditis elegans has been central to the understanding of metazoan biology. However, C. elegans is but one species among millions and the significance of this important model organism will only be fully revealed if it is placed in a rich evolutionary context. Global sampling efforts have led to the discovery of over 50 putative species from the genus Caenorhabditis, many of which await formal species description. Here, we present species descriptions for 10 new Caenorhabditis species. We also present draft genome sequences for nine of these new species, along with a transcriptome assembly for one. We exploit these whole-genome data to reconstruct the Caenorhabditis phylogeny and use this phylogenetic tree to dissect the evolution of morphology in the genus. We reveal extensive variation in genome size and investigate the molecular processes that underlie this variation. We show unexpected complexity in the evolutionary history of key developmental pathway genes. These new species and the associated genomic resources will be essential in our attempts to understand the evolutionary origins of the C. elegans model.