Extent of surgery and pathology evaluation has an impact on bladder cancer outcomes after radical cystectomy
Extent of surgery and pathology evaluation has an impact on bladder cancer outcomes after radical cystectomy
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DOI：
10.1016/s0090-4295(02)02116-7
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发表时间：
2003-01-01
期刊：
影响因子：
2.1
通讯作者：
Herr, HW
中科院分区：
文献类型：
--
作者：
Herr, HW
目标.评估手术范围和病理评估是否影响膀胱癌患者根治性膀胱切除术后的预后。对637例浸润性膀胱癌患者行根治性膀胱切除术和盆腔淋巴结清扫术的资料进行分析。研究了手术和病理变量与5年疾病特异性生存率和局部复发结局之间的关系。肿瘤病理分期和淋巴结状态是生存的重要变量。对于淋巴结阴性和淋巴结阳性的患者，生存率的提高和局部复发率的降低与手术切缘阴性和淋巴结切除数量的增加有关。手术的范围和病理学评估对膀胱癌患者术后的结果有影响。这些信息不仅对个体的治疗和预后很重要，而且对确定辅助化疗的候选者也很重要。泌尿学61：105-108，2003年。(C)2003年，Elsevier Science Inc.
Objectives. To evaluate whether the extent of surgery and of the pathology evaluation affects the outcome of patients with bladder cancer after radical cystectomy.Methods. The data from 637 patients with invasive bladder cancer who underwent radical cystectomy and pelvic lymph node dissection were analyzed. Associations between surgical and pathologic variables and 5-year disease-specific survival and local recurrence outcomes were investigated.Results. The pathologic tumor stage and node status were significant variables for survival. For both node-negative and node-positive patients, improved survival and a reduced local recurrence rate was associated with negative surgical margins and a greater number of lymph nodes removed.Conclusions. The extent of surgery and of the pathology evaluation has an impact on the outcome of patients with bladder cancer after cystectomy. Such information is important not only for therapy and the prognosis of individuals, but also for identifying candidates for adjuvant chemotherapy. UROLOGY 61: 105-108, 2003. (C) 2003, Elsevier Science Inc.