Relationship between serum resistin, body fat and inflammatory markers in females with clinical knee osteoarthritis
Relationship between serum resistin, body fat and inflammatory markers in females with clinical knee osteoarthritis
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DOI：
10.1016/j.knee.2019.12.009
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发表时间：
2020-01-01
期刊：
影响因子：
1.9
通讯作者：
Marzouki, Zuhair M.
中科院分区：
文献类型：
--
作者：
Alissa, Eman M.;Alzughaibi, Layla S.;Marzouki, Zuhair M.
目的：脂肪因子在骨关节炎（OA）的发病机制研究中引起了广泛的关注，因为它们在骨和软骨的体内平衡中起着至关重要的作用。众所周知，肥胖是OA负担的公认和可改变的原因之一。肥胖和OA之间的代谢联系的关键介质可能是抵抗素，以及脂肪组织分泌的其他细胞因子。我们的目的是评估女性膝关节OA患者血清抵抗素与肥胖和炎症的关系。方法：采用病例对照研究设计，将100名年龄在40岁以上、有症状的原发性膝关节OA的女性与100名明显健康的女性年龄相匹配。所有研究参与者都接受了临床检查、实验室检查和放射学检查。结果：原发性膝关节OA患者血清抵抗素水平高于健康对照组。我们发现血清抵抗素升高与肥胖指标、炎症指标和WOMAC指数呈正相关。在调整混杂因素后，发现高敏感性C反应蛋白是血清抵抗素水平的独立预测因子。结论：这些结果表明，抵抗素可能在膝关节OA的进展中发挥重要作用，并可能作为反映疾病严重程度的新型可靠生物标志物，有可能参与膝关节OA发病机制的基本过程。(C) 2019 Elsevier B.V.版权所有
Objectives: Adipokines have gained much interest in osteoarthritis (OA) pathogenesis studies over the past years in that they play crucial roles in bone and cartilage homeostasis. Obesity is known to be one of the well-recognized and modifiable causes of OA burden. Key mediators in this metabolic link between obesity and OA could be resistin, among other cytokines secreted by the adipose tissue. We aimed to evaluate the association of serum resistin with obesity, and inflammation in female patients with knee OA.Methods: One hundred female participants, aged above 40 years, with symptomatic primary knee OA were matched for age with 100 apparently healthy females in a case-control study design. All study participants were subjected to clinical examination, laboratory investigations and radiological examination.Results: Patients with primary knee OA had elevated levels of serum resistin compared with healthy controls. We demonstrated that elevated serum resistin positively correlated with adiposity measures, inflammatory markers and WOMAC index. High sensitivity C reactive protein was found to be an independent predictor of serum resistin levels after adjustment for confounder factors.Conclusions: These results indicate that resistin may play an important role in the progression of knee OA and may serve as a novel and reliable biomarker for reflecting disease severity, with the potential to contribute to the fundamental processes underlying the pathogenesis of knee OA. (C) 2019 Elsevier B.V. All rights reserved.