Trabecular bone structure of the calcaneus: Preliminary in vivo MR imaging assessment in men with osteoporosis
Trabecular bone structure of the calcaneus: Preliminary in vivo MR imaging assessment in men with osteoporosis
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DOI：
10.1148/radiol.2273020420
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发表时间：
2003-06-01
期刊：
影响因子：
19.7
通讯作者：
Cotten, A
中科院分区：
文献类型：
--
作者：
Boutry, N;Cortet, B;Cotten, A
目得：使用磁共振（MR）成像，以评估潜在的差异，在男性和男性之间的骨结构骨质疏松症。材料和方法：在50名男性（26例骨质疏松症患者和24名年龄匹配的健康对照组）的跟骨扫描MR图像。骨质疏松症定义为采用双能X线吸收测定法测量的低骨矿物质密度（腰椎或股骨近端低于年轻成人正常值至少2.5 SD）。17例患者有骨质疏松性骨折病史。对于每个参与者，通过使用矩形感兴趣区域分析10个连续的矢状面三维梯度回波MR切片。从这些图像中获得20个结构测量值。此外，在46名参与者中获得了跟骨密度测量值。使用未配对Student t检验计算两组之间差异的显著性。采用Logistic回归分析计算对照组每减少1 SD骨折的比值比。结果：20个结构参数中有13个参数，尤其是连接性参数在对照组和患者组之间有显著性差异（P
PURPOSE: To use magnetic resonance (MR) imaging to evaluate potential differences in bone structure between men with and men without osteoporosis.MATERIALS AND METHODS: Sagittal MR images of the calcaneus were obtained in 50 men (26 patients with osteoporosis and 24 age-matched healthy control subjects). Osteoporosis was defined as a low bone mineral density (at least 2.5 SDs below the normal value for young adults at either the lumbar spine or proximal femur) as measured with dual-energy x-ray absorptiometry. Seventeen patients had a history of osteoporotic fractures. For each participant, 10 consecutive sagittal three-dimensional gradient-echo MR sections were analyzed by using a rectangular region of interest. Twenty structural measurements were obtained from these images. Additionally, density measurements at the calcaneus were obtained in 46 participants. The significance of differences between the two groups was calculated by using the unpaired Student t test. The odds ratios for fracture per 1 SD decrease in the control group were calculated with logistic regression analysis. Adjustment for participant weight and height was performed if necessary.RESULTS: Thirteen of 20 structural parameters, especially connectivity parameters, showed significant differences between control subjects and patients (P