Heme-bound iron in treatment of pregnancy-associated iron deficiency anemia.
Heme-bound iron in treatment of pregnancy-associated iron deficiency anemia.
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DOI：
10.4103/jfmpc.jfmpc_271_18
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发表时间：
2018-11-01
影响因子：
1.4
通讯作者：
Maghrabi, Manal M
中科院分区：
文献类型：
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作者：
Abdelazim, Ibrahim A;Abu-Faza, Mohannad;Maghrabi, Manal M
背景：妊娠中期和晚期铁的需求量增加。材料与方法：对122例妊娠期缺铁性贫血（IDA）孕妇进行血红素结合铁（heme-bindediron，heme）治疗，观察其对IDA的治疗效果。研究的女性接受血红素结合铁片治疗≥3个月。比较治疗前后血红蛋白、铁蛋白、平均红细胞体积（MCV）和平均红细胞血红蛋白（MCH）的变化，以检测血红素结合铁（Optifer）治疗妊娠期IDA的疗效。平均治疗前血红蛋白从8.4 ± 2.7显著增加至11.2 ± 2.1 g/kg。在血红素结合铁治疗后3个月，平均治疗前铁蛋白水平从22.6 ± 5.6 μ g/L显著增加到112.8 ± 4.8 μ g/L（分别为P < 0.003和0.04）。此外，平均治疗前红细胞MCV和MCH分别从74.2 ± 4.8 fL和24.2 ± 7.8 pg显著增加至92.0 ± 4.1 fL和32.6 ± 6.2 pg）（P分别为0.04和0.007）血红素结合铁治疗后3个月。血红素结合铁（Optifer）是一种有效的口服铁制剂，用于治疗妊娠期间的IDA，并补充耗尽的铁储备。
BACKGROUND: The iron requirements increase during the second and third trimesters of pregnancy. Maternal anemia is a leading cause of adverse perinatal outcome.OBJECTIVES: This study was designed to evaluate the efficacy of the heme-bound iron in treatment of pregnancy-associated iron deficiency anemia (IDA).MATERIALS AND METHODS: In all, 122 women with IDA during pregnancy and hemoglobin ≤10 g/dL were studied. The studied women were treated with heme-bound iron tablets for ≥3 months. Pretreatment hemoglobin, ferritin, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) were compared with the posttreatment values to detect the efficacy of heme-bound iron (Optifer) in treatment of IDA during pregnancy.RESULTS: The mean pretreatment hemoglobin significantly increased from 8.4 ± 2.7 to 11.2 ± 2.1 g/dL and the mean pretreatment ferritin level significantly increased from 22.6 ± 5.6 to 112.8 ± 4.8 mug/L (P < 0.003 and 0.04; respectively) 3 months after heme-bound iron treatment. In addition, the mean pretreatment red blood cells' MCV and MCH significantly increased from 74.2 ± 4.8 fL and 24.2 ± 7.8 pg, respectively, to 92.0 ± 4.1 fL and 32.6 ± 6.2 pg) (P = 0.04 and 0.007, respectively) 3 months after heme-bound iron treatment.CONCLUSION: Heme-bound iron (Optifer) is an effective oral iron preparation to treat IDA during pregnancy and to replace the depleted iron store.