Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo
Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo
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DOI：
10.1152/jn.00759.2006
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发表时间：
2007-01-01
影响因子：
2.5
通讯作者：
Khazipov, Rustem
中科院分区：
文献类型：
--
作者：
Minlebaev, Marat;Ben-Ari, Yehezkel;Khazipov, Rustem
作者：J. J. M，J. M.在体新生大鼠桶状皮层纺锤波爆发振荡的网络机制。神经生理学杂志97：692-700，2007年。首次发表于2006年11月8日; doi：10.1152/jn.00759.2006。在发育早期，皮质网络产生参与皮质发育的特定活动模式。在体内，新生大鼠新皮层的主要电活动模式是空间受限的纺锤波爆发。在这里，我们研究了网络机制的新生大鼠桶皮质使用灌流皮层制备在体内产生的纺锤波。自发和感觉诱发的纺锤波爆发存在于灌流桶皮质。药理学分析表明，纺锤波爆发是由AMPA/红藻氨酸受体的主要贡献，但轻微的NMDA受体和间隙连接的突触驱动。虽然GABA能突触对起搏纺锤波爆发振荡节律的贡献最小，但周围GABA能抑制似乎对其区室化至关重要。我们建议，当地的纺锤波爆发振荡，驱动的突触和GABA能突触的空间限制，有助于桶皮层的发展在发育可塑性的关键时期。
Minlebaev M, Ben-Ari Y, Khazipov R. Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo. J Neurophysiol 97: 692-700, 2007. First published November 8, 2006; doi:10.1152/jn.00759.2006. Early in development, cortical networks generate particular patterns of activity that participate in cortical development. The dominant pattern of electrical activity in the neonatal rat neocortex in vivo is a spatially confined spindle-burst. Here, we studied network mechanisms of generation of spindle-bursts in the barrel cortex of neonatal rats using a superfused cortex preparation in vivo. Both spontaneous and sensory-evoked spindle-bursts were present in the superfused barrel cortex. Pharmacological analysis revealed that spindle-bursts are driven by glutamatergic synapses with a major contribution of AMPA/kainate receptors, but slight participation of NMDA receptors and gap junctions. Although GABAergic synapses contributed minimally to the pacing the rhythm of spindle-burst oscillations, surround GABAergic inhibition appeared to be crucial for their compartmentalization. We propose that local spindle-burst oscillations, driven by glutamatergic synapses and spatially confined by GABAergic synapses, contribute to the development of barrel cortex during the critical period of developmental plasticity.