Personalized targeted therapy for esophageal squamous cell carcinoma
Personalized targeted therapy for esophageal squamous cell carcinoma
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DOI：
10.3748/wjg.v21.i25.7648
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发表时间：
2015-07-07
影响因子：
4.3
通讯作者：
Chen, Xiaoxin
中科院分区：
文献类型：
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作者：
Kang, Xiaozheng;Chen, Keneng;Chen, Xiaoxin
食管鳞状细胞癌仍然是全世界临床医生的沉重负担。研究人员发现了食管鳞状细胞癌的基因组图谱，这为个性化肿瘤治疗的时代带来了希望。这一问题面临的最紧迫的问题之一是提高对新获得的基因组数据的理解，并确定驱动基因突变、途径和网络。大量新型靶向药物的出现为更有效的治疗方案带来了希望和宣传，但药物选择的准确性仍有争议。其他问题，如癌症异质性、耐药性、特殊反应和副作用，必须克服。这篇社论将讨论个性化肿瘤学中不断发展的主题，如基因组学数据的解释、靶向治疗中的问题、靶向治疗的研究方法和未来的观点。
Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.