IMMUNOLOGICAL STUDIES IN IGA NEPHROPATHY
IMMUNOLOGICAL STUDIES IN IGA NEPHROPATHY
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DOI：
10.1038/ki.1980.147
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发表时间：
1980-01-01
影响因子：
19.6
通讯作者：
CLARKSON, AR
中科院分区：
文献类型：
--
作者：
WOODROFFE, AJ;GORMLY, AA;CLARKSON, AR
通过固相[补体成分 1 的 q 片段]、Clq 放射免疫分析，在 78 名原发性 IgA 肾病患者中，43.6% 检测到循环免疫复合物 (CIC)。 IC 大小为中等（9 至 17S），包含 IgA、IgG 和不太常见的 IgM。 CIC 经常间歇性出现，与肉眼血尿的发作相关。血清 IgA 浓度升高 (38.7%) 与 CIC 检测不相关。在过敏性紫癜患者和与酒精性肝硬化和/或门体分流相关的 IgA 肾小球肾炎患者的血清样本中也观察到了类似的结果。导致 IC 系膜定位的因素尚不清楚；呼吸道病原体（肺炎支原体、疱疹病毒、流感）、肠道菌群（大肠杆菌07）和牛血清白蛋白的血清抗体滴度升高表明常见的外源抗原可能参与发病机制。粘膜抗原排斥或网状内皮 IC 隔离的主要缺陷被认为可以解释这些发现。
Circulating immune complexes (CIC) were detected in 43.6% of 78 patients with primary IgA nephropathy by the solid-phase [q fragment of complement component 1], Clq radioimmunoassay. The IC were intermediate (9 TO 17S) in size and contained IgA, IgG and less commonly IgM. CIC were often present intermittently, correlating with episodes of macroscopic hematuria. Elevated serum IgA concentrations (38.7%) did not correlate with the detection of CIC. Similar findings were observed in sera samples from patients with Henoch Schonlein purpura and in IgA glomerulonephritis associated with alcoholic cirrhosis and/or portal systemic shunts. The factors responsible for the mesangial localization of the IC are not clear; elevations in serum antibody titers to respiratory pathogens (Mycoplasma pneumoniae, herpes virus, influenza), gut flora (Escherichia coli 07) and bovine serum albumin suggest that common exogenous antigens may be involved in the pathogenesis. Primary defects in mucosal antigen exclusion or reticuloendothelial IC sequestration are proposed to account for these findings.