HISTOPATHOLOGICAL CHANGES IN THE BRAIN OF MICE GIVEN CLOSTRIDIUM-PERFRINGENS TYPE-D EPSILON TOXIN
HISTOPATHOLOGICAL CHANGES IN THE BRAIN OF MICE GIVEN CLOSTRIDIUM-PERFRINGENS TYPE-D EPSILON TOXIN
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DOI：
10.1016/0021-9975(84)90024-0
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发表时间：
1984-01-01
影响因子：
0.8
通讯作者：
FINNIE, JW
中科院分区：
文献类型：
--
作者：
FINNIE, JW
通过光学显微镜检查了产气荚膜梭菌D型ε毒素给药后在小鼠中产生的脑损伤的分布、严重程度和频率。小脑颗粒层是单次给予毒素的小鼠中最常受影响的区域。在注射毒素后1小时至7天检查了脑形态的连续变化。病变从最初的血管源性水肿发展为软化灶，软化灶通常是局灶性的且双侧对称，更倾向于发生在白质。讨论了这些软化区域的地形学分布。
The distribution, severity and frequency of brain lesions produced in mice by the administration of C. perfringens Type D epsilon toxin were examined by light microscopy. The granular layer of the cerebellum was the area most frequently affected in mice given single doses of toxin. Sequential changes in brain morphology were examined from 1 h to 7 days after injection of toxin. Lesions progressed from an initial vasogenic edema to malacic foci which commonly were focal and bilaterally symmetrical, with a predilection for white matter. The topographical distribution of these malacic areas is discussed.