RELEASE OF VASOACTIVE AMINES FROM RABBIT PLATELETS INDUCED BY SENSITIZED MONONUCLEAR LEUKOCYTES AND ANTIGEN
RELEASE OF VASOACTIVE AMINES FROM RABBIT PLATELETS INDUCED BY SENSITIZED MONONUCLEAR LEUKOCYTES AND ANTIGEN
复制标题
致敏单核白细胞和抗原诱导兔血小板释放血管活性胺
DOI：
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发表时间：
1970
影响因子：
15.3
通讯作者：
P. Henson
中科院分区：
文献类型：
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作者：
P. Henson
本文描述了家兔血小板通过血白细胞的免疫机制释放血管活性胺。该反应涉及来自免疫兔的白细胞、抗原和血小板，并且不需要补体系统。白细胞似乎是单核细胞，具有粘附于玻璃的能力，并且在血液中发现的数量多于脾脏、淋巴结、胸导管淋巴液、骨髓和腹腔冲洗液。对血小板的部分或全部作用似乎是由于白细胞主动释放可溶性因子，从而诱导血小板释放血管活性胺。血小板在此反应过程中不溶解，血管活性胺的释放需要血小板中代谢途径的积极参与。
The immunological release of vasoactive amines from rabbit platelets by a mechanism requiring blood leukocytes has been described. The reaction involved leukocytes from an immunized rabbit, antigen, and platelets and did not require the complement system. The leukocytes appeared to be mononuclear, had the ability to adhere to glass, and were found in greater numbers in the blood than in spleen, lymph nodes, thoracic duct lymph, bone marrow, and peritoneal cavity washings. Part or all of the effect on the platelets appeared to result from active release of a soluble factor from the leukocytes, which induced vasoactive amine release from the platelets. The platelets were not lysed during this reaction and the release of vasoactive amines required the active participation of metabolic pathways in the platelet.