Serotonin-1A receptor imaging in recurrent depression: replication and literature review
Serotonin-1A receptor imaging in recurrent depression: replication and literature review
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DOI：
10.1016/j.nucmedbio.2007.06.008
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发表时间：
2007-10-01
影响因子：
3.1
通讯作者：
Mathis, Chester
中科院分区：
文献类型：
--
作者：
Drevets, Wayne C.;Thase, Michael E.;Mathis, Chester
前言：根据体内对5-HT1AR激动剂的生理反应和死后或死前脑组织中5-HT1AR的结合，5-HT1AR的功能似乎在严重抑郁障碍(MDD)中降低。我们先前已经使用正电子发射断层扫描和[C11]Way-100635评估了抑郁症患者的5-HT1AR结合潜力(BP)，并且我们已经证实抑郁症患者(n=12)与对照组(n=8)相比，近颞叶皮质和中缝的5-HT1AR BP降低[Drists WC，Frank E，Price JC，Kupfer DJ，Holt D，Greer PJ，Huang Y，Gautier C，Mathis C.抑郁症患者5-HT1AR受体结合的PET成像。《生物精神病学》1999；46(10)：1375-87]。这些发现被一些研究重复，但不是其他研究，这些研究是在抑郁样本中进行的，这些样本更普遍地使用MDD标准进行选择。方法：应用正电子发射计算机断层扫描和[C11]Way-100635对16例抑郁症患者和8例健康对照的5-HT1AR BP进行检测。结果：MTC组5-HT1AR BP平均下降26%(P
Introduction: Serotonin-1A receptor (5-HT1AR) function appears to be decreased in major depressive disorder (MDD) based on physiological responses to 5-HT1AR agonists in vivo and to 5-HT1AR binding in brain tissues postmortem or antemortem. We have previously assessed 5-HT1AR binding potential (BP) in depression using positron emission tomography (PET) and [carbonyl-C-11]WAY-100635, and we have demonstrated reduced 5-HT1AR BP in the mesiotemporal cortex (MTC) and raphe in depressives with primary recurrent familial mood disorders (n=12) versus controls (n=8) [Drevets WC, Frank E, Price JC, Kupfer DJ, Holt D, Greer PJ, Huang Y, Gautier C, Mathis C. PET imaging of serotonin I A receptor binding in depression. Biol Psychiatry 1999;46(10):1375-87]. These findings were replicated by some, but not other, studies performed in depressed samples that were more generally selected using criteria for MDD. In the current study, we attempted to replicate our previous findings in an independent sample of subjects selected according to the criteria for primary recurrent depression applied in our prior study.Methods: Using PET and [carbonyl-C-11]WAY-100635, 5-HT1AR BP was assessed in 16 depressed subjects and 8 healthy controls.Results: Mean 5-HT1AR BP was reduced by 26% in the MTC (P