Asymmetric dual-reagent catalysis: Mannich-type reactions catalyzed by ion pair.
Asymmetric dual-reagent catalysis: Mannich-type reactions catalyzed by ion pair.
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DOI：
10.1002/anie.201409342
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发表时间：
2015-02
影响因子：
--
通讯作者：
Hongyu Wang;Kai Zhang;Changwu Zheng;Zhuo Chai;Dongdong Cao;Jiaxing Zhang;Gang Zhao
中科院分区：
文献类型：
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作者：
Hongyu Wang;Kai Zhang;Changwu Zheng;Zhuo Chai;Dongdong Cao;Jiaxing Zhang;Gang Zhao
新型双功能膦与丙烯酸酯的结合在原位生成两性离子，并通过均相离子配对模式作为不对称反应的有效催化剂。该催化体系已成功地应用于曼尼奇型反应中，取得了优异的效果，并显示出广泛的底物适用范围。这种反应性是一般有机膦催化模式所不能达到的。本文还对其机理进行了初步研究。
The combination of a new bifunctional phosphine and an acrylate generate a zwitterion in situ and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion-pairing mode. This new catalytic system has been successfully applied to Mannich-type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented.