The Correlation of Arterial Stiffness with Biophysical Parameters and Blood Biochemistry
The Correlation of Arterial Stiffness with Biophysical Parameters and Blood Biochemistry
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DOI：
10.1089/met.2016.0136
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发表时间：
2017-05-01
影响因子：
2.1
通讯作者：
Sen, Sabyasachi
中科院分区：
文献类型：
--
作者：
Khiyami, Anamil M.;Dore, Fiona J.;Sen, Sabyasachi
简介：2型糖尿病呈现出大量大血管和微血管障碍，进而导致各种合并症。在检查动脉僵硬（AS）时，可以看到血管合并症，这是内皮健康和心血管疾病风险的预测因子。脉搏波分析（PWA）和脉冲波速度（PWV）是两个用于测量AS的测试。目前，疾病状态和进展是通过血液生物化学跟踪的。监测糖尿病的这些黄金标准很昂贵且需要优化。研究问题：研究哪些生物物理和生化参数与AS最相关，这可能会减少疾病进展所需的生化测试和生物物理参数测量的数量。
Introduction: Type 2 diabetes presents with numerous macrovascular and microvascular impairments, which in turn lead to various co-morbidities. Vascular co-morbidities can be seen when examining arterial stiffness (AS), which is a predictor for endothelial health and cardiovascular disease risk. Pulse wave analysis (PWA) and pulse wave velocity (PWV) are two tests that are commonly used to measure AS. Currently, disease states and progression are tracked via blood biochemistry. These gold standards in monitoring diabetes are expensive and need optimization.Research Question: To investigate which biophysical and biochemical parameters correlated best with AS, which may reduce the number of biochemical tests and biophysical parameter measurements needed to track disease progression.Methods: Data from 42 subjects with type 2 diabetes mellitus for