Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
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DOI：
10.1073/pnas.0405775102
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发表时间：
2005-02-22
影响因子：
11.1
通讯作者：
Partridge, L
中科院分区：
文献类型：
--
作者：
Broughton, SJ;Piper, MDW;Partridge, L
胰岛素/胰岛素样生长因子样信号通路存在于所有多细胞生物体中，调节多种功能，包括生长、发育、繁殖力、代谢稳态和寿命。在果蝇中，胰岛素/胰岛素样生长因子样信号通路的配体果蝇胰岛素样肽在发育过程中调节生长和血淋巴碳水化合物稳态，并以阶段和组织特异性方式表达。在这里，我们发现，果蝇大脑中产生类胰岛素肽的中位神经分泌细胞的消融会导致成人血淋巴中的空腹血糖水平升高，类似于糖尿病哺乳动物中的情况。它们还表现出脂质和碳水化合物的储存增加、繁殖力降低以及对热和冷的耐受性降低。然而，被消融的果蝇显示出中位寿命和最大寿命的延长，以及对氧化应激和饥饿的抵抗力增强。
The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.