Increase in desipramine serum levels associated with methadone treatment.
Increase in desipramine serum levels associated with methadone treatment.
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与美沙酮治疗相关的地昔帕明血清水平升高。
DOI：
10.1176/ajp.146.12.1611
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
O'Brien,CP
中科院分区：
文献类型：
--
作者：
Maany,I;Dhopesh,V;Arndt,IO;Burke,W;Woody,G;O'Brien,CP
研究了 5 名因可卡因滥用而接受美沙酮治疗的男性退伍军人的美沙酮与地昔帕明的相互作用。每个 S 在使用地昔帕明稳定时采集了 3 个血液样本，在使用美沙酮和地昔帕明组合稳定时采集了 3 个样本。当同时接受标准剂量的地昔帕明和美沙酮时，所有 Ss 中地昔帕明的血清水平均高于单独接受地昔帕明时。平均增幅为108%。监测血浆水平可能有助于为接受美沙酮治疗计划的患者开出地昔帕明处方。（PsycINFO 数据库记录 (c) 2016 APA，保留所有权利）
Studied methadone–desipramine interactions in 5 male veterans undergoing methadone treatment for cocaine abuse. Each S had 3 blood samples taken while stabilized on desipramine and 3 samples while stabilized on the combination of methadone and desipramine. Serum levels of desipramine in all Ss were higher when receiving both desipramine and methadone at standard doses than when receiving desipramine alone. The average increase was 108%. Monitoring of plasma levels may be helpful when prescribing desipramine for patients in methadone treatment programs.(PsycINFO Database Record (c) 2016 APA, all rights reserved)