Mapping the functional anatomy of task preparation: Priming task-appropriate brain networks
Mapping the functional anatomy of task preparation: Priming task-appropriate brain networks
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DOI：
10.1002/hbm.20223
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发表时间：
2006-10-01
影响因子：
4.8
通讯作者：
Garavan, Hugh
中科院分区：
文献类型：
--
作者：
Fassbender, Catherine;Foxe, John J.;Garavan, Hugh
本研究采用功能磁共振成像（fMRI）和提示版本的侧翼范式，以阐明任务准备对随后的大脑激活模式的影响。采用混合区组和事件相关设计，研究与线索期本身相关的激活以及对不一致侧翼的线索和非线索正确反应。一些地区活跃的线索，最显着的左背外侧前额叶皮层（DLPFC），这被解释为subserving在任务集维护的作用。广泛的活动指出，正确的反应不一致的侧翼，包括双侧顶叶和额叶区域，与以前的研究一致。在这些区域的激活增加提示期后的正确反应。一个重叠的网络区域也注意到线索和正确的反应，这表明准备任务适当的解剖区域在提示期间。这些结果表明，提示期允许参与者启动大脑中与任务相关的区域，并突出了左侧DLPFC在自上而下控制中的重要性。
The present study used functional magnetic resonance imaging (fMRI) and a cued version of a flanker paradigm to elucidate the effects of task preparation on subsequent brain activation patterns. A mixed block and event-related design was employed to examine activations associated with the cue periods themselves and the cued and un-cued correct responses to incongruent flankers. A number of areas were active during the cues, most notably left dorsolateral prefrontal cortex (DLPFC), which was interpreted as subserving a role in task-set maintenance. Widespread activity was noted for correct responses to incongruent flankers, including bilateral parietal and frontal regions, consistent with previous studies. Activation was increased in these regions for correct responses after cue periods. An overlapping network of regions was also noted for cues and correct responses, suggesting preparation of task-appropriate anatomical regions during the cue period. These results suggest that cue periods allow participants to prime task-relevant areas within the brain and highlight the importance of left DLPFC in top-down control.