Variation of Cone Photoreceptor Packing Density with Retinal Eccentricity and Age
Variation of Cone Photoreceptor Packing Density with Retinal Eccentricity and Age
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DOI：
10.1167/iovs.11-7199
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发表时间：
2011-09-01
影响因子：
4.4
通讯作者：
Burns, Stephen A.
中科院分区：
文献类型：
--
作者：
Song, Hongxin;Chui, Toco Yuen Ping;Burns, Stephen A.
目的。目的研究不同年龄健康受试者视网膜视锥感受器堆积密度的变化。方法：应用高分辨率自适应光学扫描激光眼底镜(AOSLO)系统对两组不同年龄受试者的视网膜进行系统成像。10名年轻受试者(年龄范围22-35岁)和10名年长受试者(年龄范围50-65岁)被试。对四条初级视网膜经线：上、下、鼻和颞部的视锥感光细胞条带进行成像，长约12度x 1.8度。计数条带内的视锥感光细胞数，计算视锥感光细胞堆积密度。用三因素方差分析(Three-way ANOVA)计算年龄、经络和偏心度对视锥感光细胞堆积密度的交互作用。结果与预期的一样，视锥感光细胞堆积密度在接近中心凹的位置较高，随着视网膜偏心从0.18 mm增加到3.5 mm(类似于0.6-12度)，视锥感光细胞堆积密度降低。老年受试者的视锥密度约为0.18 mm处的75%(类似于0.6)，这一差异随着偏心率的增加而迅速减小，两组的视锥感光细胞填充密度平均超过0.5 mm的视网膜偏心度相似。结论：活体人类视网膜的视锥填充密度随着年龄的增加而降低，在中心凹中心发现最大的差异。各年龄组视网膜视锥密度存在经向差异，视锥感光细胞堆积密度随轴向偏心率的增加而降低的速度快于水平轴向。(投资眼科VS科学。2011年；52：7376-7384)doi：10.1167/iovs.11-7199
PURPOSE. To study the variation of cone photoreceptor packing density across the retina in healthy subjects of different ages.METHODS. High-resolution adaptive optics scanning laser ophthalmoscope (AOSLO) systems were used to systematically image the retinas of two groups of subjects of different ages. Ten younger subjects (age range, 22-35 years) and 10 older subjects (age range, 50-65 years) were tested. Strips of cone photoreceptors, approximately 12 degrees x 1.8 degrees long were imaged for each of the four primary retinal meridians: superior, inferior, nasal, and temporal. Cone photoreceptors within the strips were counted, and cone photoreceptor packing density was calculated. Statistical analysis (three-way ANOVA) was used to calculate the interaction for cone photoreceptor packing density between age, meridian, and eccentricity.RESULTS. As expected, cone photoreceptor packing density was higher close to the fovea and decreased with increasing retinal eccentricity from 0.18 to 3.5 mm (similar to 0.6-12 degrees). Older subjects had approximately 75% of the cone density at 0.18 mm (similar to 0.6), and this difference decreased rapidly with eccentricity, with the two groups having similar cone photoreceptor packing densities beyond 0.5 mm retinal eccentricity on average.CONCLUSIONS. Cone packing density in the living human retina decreases as a function of age within the foveal center with the largest difference being found at our most central measurement site. At all ages, the retina showed meridional difference in cone densities, with cone photoreceptor packing density decreasing faster with increasing eccentricity in the vertical dimensions than in the horizontal dimensions. (Invest Ophthalmol Vis Sci. 2011;52:7376-7384) DOI:10.1167/iovs.11-7199