Reversion of the mouse pink-eyed unstable mutation induced by low doses of x-rays.
Reversion of the mouse pink-eyed unstable mutation induced by low doses of x-rays.
复制标题
低剂量 X 射线诱导的小鼠红眼不稳定突变的逆转。
DOI：
10.1126/science.7985029
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Carls,N
中科院分区：
文献类型：
--
作者：
Schiestl,RH;Khogali,F;Carls,N
辐射可导致基因组的缺失和其他重排，并与致癌作用和遗传性疾病有关。老鼠的粉红色眼睛不稳定（双关语）突变是由基因复制引起的，并通过删除一个拷贝恢复为野生型。小鼠胚胎中的逆转事件被检测为动物皮毛上的黑色斑点或在显微镜下为无色毛发背景中的部分黑色毛发。部分黑发的频率增加了X射线在非常低的剂量。在1 ~ 100厘戈瑞范围内呈线性剂量-反应关系。
Deletions and other genome rearrangements can be caused by radiation and are associated with carcinogenesis and inheritable diseases. Thepink-eyed unstable(pun) mutation in the mouse is caused by a gene duplication and reverts to wild type by deletion of one copy. Reversion events in the mouse embryo were detected as black spots on the fur of the animals or microscopically as partially black hair in a background of colorless hair. The frequency of partially black hair was increased by x-rays at very low doses. A linear dose-response relation was found between 1 and 100 centigray.