Impact of high-protein diets with either moderate or low carbohydrate on weight loss, body composition, blood pressure and glucose tolerance in rats
Impact of high-protein diets with either moderate or low carbohydrate on weight loss, body composition, blood pressure and glucose tolerance in rats
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DOI：
10.1017/s0007114507691934
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发表时间：
2007-06-01
影响因子：
3.6
通讯作者：
Maloney, Christopher
中科院分区：
文献类型：
--
作者：
Lobley, Gerald E.;Bremner, David M.;Maloney, Christopher
实现体重减轻和减少肥胖和相关发病率的一种方法涉及高蛋白、低碳水化合物（HPLC）饮食。本研究比较了HPLC和高蛋白、中等碳水化合物（HPMC）饮食对饮食诱导肥胖（DIO）大鼠代谢健康的影响。将磨损的雄性大鼠喂食37%脂肪饮食（n 48）或储备颗粒（n 12）22周。与普通饲料相比，喂食37%脂肪饲料的大鼠积累了更多的体脂（26.6%对14.8%体重，P < 0.001）。DIO大鼠在口服葡萄糖耐量试验后具有更高的收缩压（+ 6.6 mmHg，P= 0.002）、空腹胰岛素（+63% P= 0.006）以及葡萄糖（+21%，P < 0.001）和胰岛素（+81%，P< 0.001）曲线下面积。然后将DIO大鼠分成四组并提供8周：（1）37%脂肪饮食;（2）HPLC或（3）HPMC饮食;或（4）饲喂37%脂肪饮食至HPMC组的摄入量。大鼠提供37%的脂肪或HPLC饮食增加，而那些对HPMC失去身体脂肪。血压并没有因为饮食的改变而改变。HPLC和HPMC大鼠均降低了空腹胰岛素（P=0.027），并改善了稳态评估（HOMA; P=0.011），与储备动物无差异。尽管脂肪增加存在差异，但这些改善仍然发生，并且表明体重减轻和大量营养素摄入都可以对肥胖相关的发病率产生有利影响。
One approach to achieve weight loss and decrease both obesity and associated morbidities involves high-protein, low-carbohydrate (HPLC) diets. This study compares the impact on metabolic health of HPLC and high-protein, medium-carbohydrate (HPMC) diets offered to diet-induced obese (DIO) rats. Wearding male rats were fed either a 37 % fat diet (n 48) or stock pellets (n 12) for 22 weeks. Rats fed the 37 % fat diet accumulated more body fat (26.6 versus 14.8 % body weight, P < 0.001) compared with those on stock diet. The DIO rats had higher systolic blood pressure (+ 6.6 mmHg, P= 0.002), fasting insulin (+ 63 % P= 0.006) and areas under the glucose (+ 21 %, P < 0.001) and insulin (+ 81 %, P< 0.001) curves following an oral glucose tolerance test. DIO rats were then separated into four groups and offered for 8 weeks either: ( 1) the 37 % fat diet; (2) an HPLC or (3) HPMC diet; or (4) fed the 37 % fat diet to the intake of the HPMC group. Rats offered the 37 % fat or HPLC diets gained while those on HPMC lost body fat. Blood pressure was not altered by the dietary switch. Both HPLC and HPMC rats had lowered fasting insulin (P=0.027) and improved homeostatic assessment (HOMA; P=0.011) that was not different from those of stock animals. These improvements occurred despite differences in fat gain, and indicate that both weight loss and macronutrient intake can impact favourably on obesity-associated morbidities.