Immunologic response to infection and its role in septic shock
Immunologic response to infection and its role in septic shock
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DOI：
10.1016/s0749-0704(05)70107-x
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发表时间：
2000-04-01
影响因子：
4.3
通讯作者：
Casey, LC
中科院分区：
文献类型：
--
作者：
Casey, LC
这篇文章探讨了当细菌穿透我们的皮肤或粘膜表面时发生的事件，引发了强烈的宿主反应，包括补体激活，抗体形成（最初是胸腺独立的，最终是胸腺依赖的），吞噬作用，抗菌肽和蛋白质的产生，氧自由基，细胞因子的产生，以及凝血系统的激活。如果强烈的宿主反应的介质溢出到体循环中，则会导致多系统器官衰竭和潜在的死亡。
This article explores the events that take place when bacteria penetrate our skin or mucosal surfaces triggering a vigorous host response including complement activation, antibody formation (initially thymus-independent and eventually thymus-dependent), phagocytosis, production of antibacterial peptides and proteins, oxygen free radicals, the production of cytokines, and activation of the coagulation system. If the mediators of the vigorous host response spill into the systemic circulation, there is resulting multisystem organ failure and potential mortality.