Protein-Mediated Shape Control of Silver Nanoparticles
Protein-Mediated Shape Control of Silver Nanoparticles
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DOI：
10.1021/acs.bioconjchem.8b00034
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发表时间：
2018-04-01
影响因子：
4.7
通讯作者：
Parak, Wolfgang J.
中科院分区：
文献类型：
--
作者：
Chakraborty, Indranath;Feliu, Neus;Parak, Wolfgang J.
银纳米粒子是在水溶液中生长的，不存在典型的表面活性分子，但存在不同的蛋白质。由此得到的银纳米颗粒的形状可以通过选择蛋白质的类型来调整。可及赖氨酸基团的数量被发现是纳米颗粒形成各向异性的主要原因。暴露在蛋白封顶的球形或棱柱状纳米颗粒中的细胞活力测量没有显示出这两种几何形状之间的差异。因此，在只有蛋白质包覆的银纳米颗粒的情况下，在调查的暴露条件下没有发现形状诱导的毒性。
Silver nanoparticles were grown in aqueous solution, without the presence of typical surfactant molecules, but under the presence of different proteins. The shape of the resulting silver nanoparticles could be tuned by the selection of the types of proteins. The amount of accessible lysine groups was found to be mainly responsible for the anisotropy in nanoparticle formation. Viability measurements of cells exposed to protein capped spherical or prism-shaped NPs did not reveal differences between both geometries. Thus, in the case of protein-only coated Ag NPs, no shape-induced toxicity was found under the investigated exposure conditions.