Turnover of Iodine-131-labelled Ceruloplasmin in Human Beings
Turnover of Iodine-131-labelled Ceruloplasmin in Human Beings
复制标题
碘 131 标记的铜蓝蛋白在人体中的周转
作者：
M. Kekki;P. Koskelo;E. Nikkilä
血浆铜蓝蛋白分子是α-2-球蛋白组分的一种成分，含有90%以上的血浆铜。其浓度在正常人血清和不同的病理条件下的变化已被广泛研究1。然而，其功能和周转动力学知之甚少。显然，铜蓝蛋白在体内至少部分地作为氧化酶。Gitlin和Hughes用碘-131标记铜蓝蛋白，并在5名患有无关慢性疾病的患者中获得了5-7天的生物半衰期2。发现131 I标记的人血浆铜蓝蛋白在小鼠中的生物半衰期为0.92天3。在这里报告的工作中，铜蓝蛋白的营业额进行了调查，在人类的131碘标记的制剂。
THE ceruloplasmin molecule, a component of the α-2-globulin fraction, contains more than 90 per cent of the plasma copper. Variations in its concentration in the sera of normal individuals and in different pathological conditions have been extensively investigated1. Little is known, however, of its function and turnover kinetics. It is evident that ceruloplasmin acts, at least in part, as an oxidase in vivo. Gitlin and Hughes labelled ceruloplasmin with iodine-131 and obtained a biological half-life of 5–7 days in five persons with unrelated chronic disease2. The biological half-life of 131I-labelled human ceruloplasmin in mice was found to be 0.92 days3. In the work reported here, the turnover of ceruloplasmin was investigated in human beings by means of an 131I-labelled preparation.