Do Fungi Undergo Apoptosis-Like Programmed Cell Death?
Do Fungi Undergo Apoptosis-Like Programmed Cell Death?
复制标题
真菌会发生类似凋亡的程序性细胞死亡吗？
DOI：
10.1128/mbio.00948-18
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发表时间：
2018-07-01
期刊：
影响因子：
6.4
通讯作者：
Hardwick, J. Marie
中科院分区：
文献类型：
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作者：
Hardwick, J. Marie
真菌是否会经历类似真菌病的程序性细胞死亡，这个问题可以分为两个问题。一个问题是关于将术语“凋亡”应用于真菌，另一个是一个更具挑战性的问题，即真菌是否已经进化出造成自我伤害的机制。这两个问题的答案取决于“细胞凋亡”和“程序性细胞死亡”的定义。“考虑到这些和其他细胞死亡术语是如何起源的，以及目前对动物的定义，当这些术语应用于真菌时会出现一些混乱。虽然很难为真菌细胞凋亡的概念辩护，但更有趣的问题是，真菌最终是否会被发现编码编程或即兴的自我破坏过程，正如有趣的新发现所表明的那样。
This question of whether fungi undergo apoptosis-like programmed cell death can be separated into two questions. One question is about applying the term "apoptosis" to fungi, and the other is a more challenging question of whether fungi have evolved mechanisms that inflict self-injury. The answers to both questions depend on the definitions applied to "apoptosis" and "programmed cell death." Considering how these and other cell death terms originated and are currently defined for animals, some confusion arises when the terms are applied to fungi. While it is difficult to defend the concept of fungal apoptosis, the more interesting issue is whether fungi will eventually be found to encode programmed or extemporaneous self-destructive processes, as suggested by intriguing new findings.