GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis.
GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis.
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DOI：
10.20455/ros.2019.835
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发表时间：
2019-05-01
期刊：
影响因子：
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通讯作者：
Robert Li, Y
中科院分区：
文献类型：
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作者：
Zhu, Hong;Santo, Arben;Robert Li, Y
虽然众所周知，细菌感染是脓毒症的主要原因，但这种临床综合征的分子病理生理学仍不清楚。在这篇研究亮点文章中，我们讨论了最近的研究结果，即谷胱甘肽过氧化物酶-4(Gpx4)通过调节铁下垂和下垂在细菌感染和多菌败血症中的保护作用，这是调节细胞死亡的两种新模式。提示Gpx4是铁性下垂和下睑下垂的必经通道，可作为开发有效控制感染和败血症药物的重要分子靶点。
While it is well known that bacterial infection is the predominant cause of sepsis, the molecular pathophysiology of this clinical syndrome remains ill-defined. In this Research Highlights article, we discuss the recent research findings regarding a protective role for glutathione peroxidase-4 (GPx4) in bacterial infection and polymicrobial sepsis via modulating ferroptosis and pyroptosis, two novel modes of regulated cell death. It is suggested that GPx4, being a requisite gateway to both ferroptosis and pyroptosis, may serve as a critical molecular target for developing effective drugs for controlling infection and sepsis.