Isolation of a cDNA encoding the human GM2 activator protein.
Isolation of a cDNA encoding the human GM2 activator protein.
复制标题
分离编码人 GM2 激活蛋白的 cDNA。
DOI：
10.1016/0014-5793(89)81454-1
复制
发表时间：
1989
期刊：
影响因子：
3.5
通讯作者：
Sandhoff,K
中科院分区：
文献类型：
--
作者：
Schröder,M;Klima,H;Nakano,T;Kwon,H;Quintern,LE;Gärtner,S;Suzuki,K;Sandhoff,K
The GM2activator protein is a glycolipid-binding protein required for the lysosomal degradation of ganglioside GM2. A human fibroblast cDNA library was screened with mixtures of oligonucleotide probes corresponding to four different areas of the amino acid sequence. A putative clone (821 bp) which gave positive signals to all four probe mixtures was purified and sequenced. The sequence was colinear with the sequence of 160 amino acids of the mature GM2activator protein. Availability of the cDNA clone should facilitate investigation into function of the GM2activator protein and also into genetic abnormalities underlying GM2gangliosidosis AB variant.
