Halothane and Enflurane Protect Against Bronchospasm in an Asthma Dog Model
Halothane and Enflurane Protect Against Bronchospasm in an Asthma Dog Model
复制标题
氟烷和安氟烷可预防哮喘犬模型中的支气管痉挛
DOI：
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发表时间：
1978
影响因子：
5.7
通讯作者：
N. A. Bergman
中科院分区：
文献类型：
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作者：
C. Hirshman;N. A. Bergman
6只先前对蛔虫抗原致敏的狗，用气溶蛔虫抗原通风10分钟，诱发实验性哮喘。当肺容量超过功能剩余容量200ml时，通过同时测量压力和流量来计算肺阻力。吸入蛔虫抗原前，硫喷妥钠麻醉犬的肺阻力为2.35±0.56(平均值±Sm)em H2O/L/秒。给药结束20min后，加用硫喷妥钠的犬肺阻力为5.72±1.29，用0.87%吸入浓度氟烷麻醉的犬肺阻力为3.18±0.62，用2.2%吸入浓度的安氟醚麻醉的犬肺阻力为3.03±0.60。这些肺阻力反应的差异在0.05水平上具有统计学意义。在蛔虫抗原犬哮喘模型中，氟烷和安氟醚在降低肺阻力方面同样有效。
Experimental asthma was induced in 6 dogs previously sensitized to ascaris antigen by ventilating them with aerosolyzed ascaris antigen far 10 minutes. Pulmonary resistance was calculated from simultaneous pressure and flow measurements at a lung volume 200 ml above functional residual capacity. Prior to administration of aerosolyzed ascaris antigen, pulmonary resistance was 2.35 ± 0.56 (mean ± SEM) em H2O/L/sec in dogs anesthetized with thiopental. Twenty minutes after the end of ascaris antigen administration, pulmonary resistance was 5.72 ± 1.29 in dogs given additional thiopental, 3.18 ± 0.62 in dogs anesthetized with halothane (0.87% inspired concentration), and 3.03 ± 0.60 in dogs anesthetized with enflurane (2.2% inspired concentration). These differences in responses of pulmonary resistance were statistically significant at 0.05 level.Halothane and enflurane were equally effective in decreasing pulmonary resistance in an ascaris antigen dog model of asthma.