COVID-19 and healthcare workers: A systematic review and meta-analysis.
COVID-19 and healthcare workers: A systematic review and meta-analysis.
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DOI：
10.1016/j.ijid.2021.01.013
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Ho SB
中科院分区：
文献类型：
--
作者：
Gholami M;Fawad I;Shadan S;Rowaiee R;Ghanem H;Hassan Khamis A;Ho SB
新型冠状病毒疫情令前线医护人员所面对的挑战及风险备受关注。本研究旨在描述HCW中SARS-CoV-2感染的临床结局和危险因素。对三个数据库进行了调查，确定了328篇文章。其中，225篇文章不符合纳入标准;因此，对97篇全文文章进行了审查。最后，经过进一步修订，30篇文章被纳入系统评价，28篇用于荟萃分析。28项研究涉及119，883例患者。患者的平均年龄为38.37岁（95% CI 36.72-40.03），男性占HCW人群的21.4%（95% CI 12.4-34.2）。HCW COVID-19检测阳性的百分比为51. 7%（95% CI 34. 7 - 68. 2）。7项研究中合并症的总患病率为18.4%（95%CI 15.5-21.7）。最常见的症状为发热27.5%（95%CI 17.6-40.3）和咳嗽26.1%（95%CI 18.1-36）。13项研究的住院率为15.1%（95% CI 5.6-35），12项研究的死亡率为1.5%（95% CI 0.5-3.9）。有感染和无感染的HCW比较显示，与个人防护设备、工作场所环境、职业、暴露、接触和检测相关的COVID-19相对风险增加。于COVID-19大流行的首6个月，据报有大量医护人员感染COVID-19，住院率为15. 1%，死亡率为1. 5%。随着大流行的发展和卫生系统的适应，需要进一步的数据来跟踪HCW的持续风险。
The COVID-19 pandemic has focused attention on the challenges and risks faced by frontline healthcare workers (HCW). This study aimed to describe the clinical outcomes and risk factors for SARS-CoV-2 infection in HCW. Three databases were surveyed and 328 articles were identified. Of these, 225 articles did not meet inclusion criteria; therefore, 97 full-text article were reviewed. Finally, after further revision, 30 articles were included in the systematic review and 28 were used for meta-analysis. Twenty-eight studies were identified involving 119,883 patients. The mean age of the patients was 38.37 years (95% CI 36.72–40.03) and males comprised 21.4% (95% CI 12.4–34.2) of the population of HCW. The percentage of HCW who tested positive for COVID-19 was 51.7% (95% CI 34.7–68.2). The total prevalence of comorbidities in seven studies was 18.4% (95% CI 15.5–21.7). The most prevalent symptoms were fever 27.5% (95% CI 17.6–40.3) and cough 26.1% (95% CI 18.1–36). The prevalence of hospitalisation was 15.1% (95% CI 5.6–35) in 13 studies and of death was 1.5% (95% CI 0.5–3.9) in 12 studies. Comparisons of HCW with and without infection showed an increased relative risk for COVID-19 related to personal protective equipment, workplace setting, profession, exposure, contacts, and testing. A significant number of HCW were reported to be infected with COVID-19 during the first 6 months of the COVID-19 pandemic, with a prevalence of hospitalisation of 15.1% and mortality of 1.5%. Further data are needed to track the continued risks in HCW as the pandemic evolves and health systems adapt.
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