Intensity and precision of circadian wheel running in three outbred rat strains.
Intensity and precision of circadian wheel running in three outbred rat strains.
复制标题
三种近交系大鼠品系中昼夜节律轮运行的强度和精度。
DOI：
10.1016/0031-9384(90)90162-w
复制
发表时间：
1990
影响因子：
2.9
通讯作者：
Bauer,MS
中科院分区：
文献类型：
--
作者：
Bauer,MS
实验大鼠被广泛应用于神经生物学和行为学研究的许多领域。然而，对昼夜活动节律的研究通常采用其他啮齿动物物种，它们的活动模式更容易在昼夜节律范式中进行测量。然而，在某些昼夜节律功能的研究中，大鼠可能是最佳选择，因为关于这种物种的神经解剖学和神经药理学的数据非常丰富。这项研究是为了确定大鼠品系的选择是否会影响测量的昼夜活动数据的质量。对三种常见的近交系大鼠，Long-Evans，Wistar和Spraogue-Dawley的轮子运行强度(每天轮子转速)、起始精度和一致可解释的运行记录的寿命进行了评估。Long-Evans大鼠在持续黑暗中自由跑步4周和8周时，表现出更高的车轮运动强度。三个品系在跑起跑的精确度上没有差异。因此，使用Long-Evans品系，具有更高的车轮运行强度和相似的活动开始精度，可能在涉及测量大鼠昼夜活动节律的研究中具有优势。
The laboratory rat is widely used in many areas of neurobiologic and behavioral research. However, studies of circadian activity rhythms have usually employed other rodent species whose activity patterns are more amenable to measurement in the circadian paradigm. Nevertheless, the rat may be the optimal choice in certain investigations of circadian function because of the wealth of data on the neuroanatomy and neuropharmacology of this species. This study was undertaken to determine whether choice of rat strain could affect the quality of measured circadian activity data. Intensity of wheel running (wheel revolutions per day), precision of onset, and longevity of consistently interpretable running records were assessed in three common outbred rat stains, Long-Evans, Wistar, and Sprague-Dawley. Long-Evans rats showed greater intensity of wheel running while entrained and at four and eight weeks of free running in constant darkness. There was no difference in precision of running onset among the three strains. Thus, use of the Long-Evans strain, with its greater intensity of wheel running and similar precision of activity onset, may confer advantages in studies involving measurement of circadian activity rhythms in the rat.