MATERNAL SELENIUM DEFICIENCY ENHANCES THE FETOLETHAL TOXICITY OF METHYL MERCURY
MATERNAL SELENIUM DEFICIENCY ENHANCES THE FETOLETHAL TOXICITY OF METHYL MERCURY
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DOI：
10.1016/0041-008x(87)90207-9
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发表时间：
1987-05-01
影响因子：
3.8
通讯作者：
IMURA, N
中科院分区：
文献类型：
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作者：
NISHIKIDO, N;FURUYASHIKI, K;IMURA, N
以ICR品系小鼠为研究对象，研究了母体缺硒对甲基汞胎儿毒性的影响。给孕鼠喂以酵母为基础的低硒饲料或补硒饲料，两者与前者相同，不同之处在于每千克饲料中添加0.1、0.2或0.4毫克硒作为亚硫酸钠。当母亲在怀孕13、14和15天每天sc给予甲基汞(MMC)15、25或35微克/公斤(MMC)时，母亲的硒缺乏会加剧甲基汞的致死性。日粮中十分之一的硒足以保护胎儿免受MMC胎死率的影响，当DAMS每天摄入25微克/公斤MMC时。母亲和胎儿组织中的汞浓度与膳食中的硒水平无关。母体组织中的硒浓度和谷胱甘肽过氧化物酶(GSH-Px)活性不受MMC影响。另一方面，补硒组母鼠胎肝中Se浓度升高，GSH-Px活性降低。因此，就GSH-Px活性而言，母体注射MMC可显著降低胎肝中硒的生物利用率。胎肝中硒含量的增加可能在MMC的胚胎毒性保护中起重要作用，只有补硒组才有此现象。
The effect of maternal selenium deficiency on methyl mercury fetotoxicity was examined in the ICR strain of mice. Pregnant mice were fed either selenium-deficient diets based on torula yeast or selenium-supplemented diets which were identical to the former except that 0.1, 0.2, or 0.4 mg of selenium per kilogram of diet was added as sodium selenite. Fetolethality of methyl mercury was exacerbated by maternal selenium deficiency when mothers were administered sc 15, 25, or 35 .mu.mol/kg/day of methylmercuric chloride (MMC) on the 13, 14, and 15th days of pregnancy. One-tenth part per million of selenium in the diet was sufficient to protect the fetuses against MMC fetolethality when dams were administered 25 .mu.mol/kg/day of MMC. Mercury concentrations in maternal and fetal tissues were independent of the dietary selenium level. Selenium concentration and glutathione peroxidase (GSH-Px) activity in maternal tissues were unaffected by MMC administration. In fetal liver, on the other hand, selenium concentration was increased and GSH-Px activity was decreased concurrently by maternal MMC administration in the selenium-supplemented groups. Therefore, as far as GSH-Px activity was concerned, the bioavailability of selenium was markedly decreased in fetal liver by maternal injection of MMC. The increase in selenium content in fetal liver, which was observed only in the selenium-supplemented groups, may play an important role in protection against fetolethal toxicity of MMC.