Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis.
Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis.
复制标题
亚甲基四氢叶酸还原酶 C677T 基因多态性与轻度认知障碍易感性的关联：系统评价和荟萃分析
DOI：
10.1155/2021/2962792
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发表时间：
2021
影响因子：
2.8
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Sun J;Jiang X;Zhao M;Ma L;Pei H;Liu N;Li H
亚甲基四氢叶酸还原酶 (MTHFR) C677T (rs1801133) 基因多态性与阿尔茨海默病风险增加有关；然而，这种关联是否适用于轻度认知障碍（MCI）仍不清楚。 我们进行了这项荟萃分析，以评估 MTHFR C677T (rs1801133) 基因变异对 MCI 风险的影响。 PubMed、Embase、Web of Science 和中国国家知识基础设施数据库的检索时间为从建库到 2021 年 3 月 21 日，语言仅限于英文或中文。我们使用固定或随机效应来检查 MTHFR C677T (rs1801133) 基因变异与 MCI 易感性之间的关联。生成了合并比值比 (OR) 和 95% 置信区间 (CI) 的森林图。 本荟萃分析包含 8 篇文章，涉及 2,175 名参与者。在等位基因（OR，1.318；95% CI，0.964-1.801；p = 0.084）、显性（OR，1.296；95% CI，0.925-1.817；p = 0.132）下，MTHFR C677T（rs1801133）基因变异与 MCI 易感性之间没有显着相关性。隐性（OR，1.397；95% CI，0.845–2.312；p = 0.193）、杂合子（OR，1.031；95% CI，0.855–1.243；p = 0.749）或纯合子（OR，1.506；95% CI，0.850–2.667； p = 0.160) 模型。 结果提示MTHFR C677T (rs1801133)基因多态性与MCI易感性无关。然而，需要涵盖各种因素的大规模研究。
Methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) gene polymorphisms are related to a growing risk of Alzheimer's disease; however, whether this association applies to mild cognitive impairment (MCI) remains unclear. We conducted this meta-analysis to evaluate the contribution of MTHFR C677T (rs1801133) gene variants to the risk of MCI. PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases were searched from their inception to March 21, 2021, with language restricted to English or Chinese. We used fixed or random effects to examine the association between MTHFR C677T (rs1801133) gene variants and MCI susceptibility. Forest plots of pooled odds ratios (ORs) and 95% confidence intervals (CIs) were generated. Eight articles with 2,175 participants were included in the present meta-analysis. There was no significant association between MTHFR C677T (rs1801133) gene variants and MCI susceptibility under the allelic (OR, 1.318; 95% CI, 0.964–1.801; p = 0.084), dominant (OR, 1.296; 95% CI, 0.925–1.817; p = 0.132), recessive (OR, 1.397; 95% CI, 0.845–2.312; p = 0.193), heterozygous (OR, 1.031; 95% CI, 0.855–1.243; p = 0.749), or homozygous (OR, 1.506; 95% CI, 0.850–2.667; p = 0.160) models. The results suggest that MTHFR C677T (rs1801133) gene polymorphisms are not associated with MCI susceptibility. However, large-scale studies covering various factors are required.