Regulation of chromosome speeds in mitosis.
Regulation of chromosome speeds in mitosis.
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DOI：
10.1007/s12195-013-0297-4
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发表时间：
2013-12
影响因子：
2.8
通讯作者：
McIntosh JR
中科院分区：
文献类型：
--
作者：
Betterton MD;McIntosh JR
当染色体被分离以准备细胞分裂时，它们的运动相对于许多电机酶移动其细胞货物的速度(160-1000 nm/S，有时甚至更快)和微管解聚的速度(~200 nm/S)而言是缓慢的(~16 nm/S)。事实上，后期染色体的速度是如此之慢，以至于粘性阻力对产生相关作用力的机制几乎没有施加什么负载。现有证据表明，染色体的速度是由某种形式的调控造成的。例如，大染色体和小染色体的移动速度大致相同，走得更远的染色体比其他染色体移动得更快，而染色体的速度既受温度的影响，也受实验中施加的负载的影响。在这篇文章中，我们回顾了关于这些现象的数据，并就调节染色体速度的机制的可能特性提出了我们的想法。
When chromosome are being separated in preparation for cell division, their motions are slow (~16 nm/s) relative to the speed at which many motor enzymes can move their cellular cargoes (160–1000 nm/s and sometimes even faster) and at which microtubules (MTs) depolymerize (~200 nm/s). Indeed, anaphase chromosome speeds are so slow that viscous drag puts little load on the mechanisms that generate the relevant forces. Available evidence suggests that chromosome speed is due to some form of regulation. For example, big and little chromosomes move at about the same speed, chromosomes that have farther to go move faster than others, and chromosome speed is affected by both temperature and an experimentally applied load. In this essay we review data on these phenomena and present our ideas about likely properties of the mechanisms that regulate chromosome speed.
关于后期A的机理：微管拆卸需要ATP而不是极力的产生ATP。
影响因子：
7.8
作者：
Spurck, T P;Pickett-Heaps, J D
通讯作者：
Pickett-Heaps, J D