Differential effects of pravastatin on the pharmacokinetics of paroxetine in normal and diabetic rats
Differential effects of pravastatin on the pharmacokinetics of paroxetine in normal and diabetic rats
复制标题
普伐他汀对正常和糖尿病大鼠帕罗西汀药代动力学的差异影响
DOI：
10.3109/00498254.2016.1154999
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发表时间：
2017-01
期刊：
影响因子：
1.8
通讯作者：
Liu Xiao-dong
中科院分区：
文献类型：
--
作者：
Li Feng;Ling Zhao-li;Wang Zhong-jian;Zhong Ze-yu;Shu Nan;Zhang Mian;Liu Can;Liu Li;Liu Xiao-dong
1. Diabetes is often accompanied with depression and hypercholesterolemia. It is possible that paroxetine and pravastatin are co-administered to diabetic patients. The aim of this study was to research the differential effect of pravastatin on plasma exposure of paroxetine in normal and diabetic rats.2. Pharmacokinetics of paroxetine was investigated following oral administration of paroxetine with and without pravastatin in normal and diabetic rats. Effects of pravastatin on metabolism, intestinal absorption and hepatic uptake of paroxetine were investigated. Activity and expression of hepatic Oatp1 and Oatp2 were also assessed.3. Pravastatin decreased plasma exposure of paroxetine in normal rats, but increased exposure of paroxetine in diabetic rats. Pravastatin neither affected metabolism nor intestinal absorption of paroxetine. Data from hepatocytes demonstrated that hepatic uptake of paroxetine were involved in Oatp1 and Oatp2. Diabetes suppressed Oatp1 activity and expression, but enhanced Oatp2 activity and expression. Pravastatin stimulated Oatp1 but inhibited Oatp2 activity.4. We concluded that differential effects of pravastatin on plasma exposure of paroxetine in normal and diabetic rats was partly due to the fact that diabetes suppressed Oatp1 activity and expression but enhanced Oatp2 activity and expression as well as that pravastatin stimulated Oatp1 activity but inhibited Oatp2 activity.
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影响因子：
7.7
作者：
Gülseren, L;Gülseren, S;Mete, L
通讯作者：
Mete, L
影响因子：
2.9
作者：
C. Transon;T. Leemann;P. Dayer
通讯作者：
C. Transon;T. Leemann;P. Dayer
影响因子：
2.1
作者：
Michiaki Abe;T. Toyohara;A. Ishii;Takehiro Suzuki;N. Noguchi;Yasutoshi Akiyama;H. Shiwaku;Rie Nakagomi-Hagihara;Guodong Zheng;E. Shibata;Tomokazu Souma;Tomohiko Shindo;H. Shima;Yoichi Takeuchi;Eikan Mishima;M. Tanemoto;T. Terasaki;T. Onogawa;M. Unno;S. Ito;S. Takasawa;T. Abe
通讯作者：
Michiaki Abe;T. Toyohara;A. Ishii;Takehiro Suzuki;N. Noguchi;Yasutoshi Akiyama;H. Shiwaku;Rie Nakagomi-Hagihara;Guodong Zheng;E. Shibata;Tomokazu Souma;Tomohiko Shindo;H. Shima;Yoichi Takeuchi;Eikan Mishima;M. Tanemoto;T. Terasaki;T. Onogawa;M. Unno;S. Ito;S. Takasawa;T. Abe
DOI：
10.1016/s1385-299x(03)00016-3
发表时间：
2003-03-01
期刊：
BRAIN RESEARCH PROTOCOLS
影响因子：
--
作者：
Klein, C;Pillot, T;Drouet, B
通讯作者：
Drouet, B
高脂饮食联合注射链脲佐菌素诱导糖尿病大鼠维拉帕米的药代动力学
影响因子：
1.8
作者：
Chen, G. M.;Hu, N.;Liu, X. D.
通讯作者：
Liu, X. D.