EFFICIENT REMOVAL OF ALBUMIN-BOUND FURANCARBOXYLIC ACID BY PROTEIN-LEAKING HEMODIALYSIS
EFFICIENT REMOVAL OF ALBUMIN-BOUND FURANCARBOXYLIC ACID BY PROTEIN-LEAKING HEMODIALYSIS
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DOI：
10.1159/000168887
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发表时间：
1995-11-01
影响因子：
4.2
通讯作者：
MIYAZAKI, T
中科院分区：
文献类型：
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作者：
NIWA, T;ASADA, H;MIYAZAKI, T
呋喃羧酸（3-羧基-4-甲基-5-丙基-2-呋喃丙酸，CMPF）是一种红细胞生成抑制剂，由于其与白蛋白的强结合，无法通过常规血液透析清除，导致其在尿毒症血清中蓄积。我们对8例尿毒症患者进行了4个月的BK-F型透析器蛋白渗漏性血液透析，以观察其对血清CMPF水平的影响。透析前血清CMPF水平在蛋白渗漏透析4个月后显著下降至约50%，而BUN和血清肌酐无显著变化。透析前红细胞压积和血红蛋白水平显着增加蛋白泄漏的血液透析。这些结果表明，蛋白渗漏血液透析降低血清白蛋白结合CMPF水平，改善贫血。
Furancarboxylic acid (3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, CMPF), an inhibitor of erythropoiesis, cannot be removed by conventional hemodialysis due to its strong albumin binding, resulting in its accumulation in uremic serum. We used protein-leaking hemodialysis with BK-F dialyzers in 8 uremic patients for 4 months to determine its effect on the serum levels of CMPF. Pre-hemodialysis serum levels of CMPF significantly decreased to about 50% after 4 months by protein-leaking hemodialysis, while those of BUN and serum creatinine did not change significantly. Pre-hemodialysis hematocrit and hemoglobin levels significantly increased by protein-leaking hemodialysis. These results indicate that protein-leaking hemodialysis reduces serum levels of albumin-bound CMPF and improves anemia.