Laterality of Attentional Networks in Patients With Cerebral Small Vessel Disease
Laterality of Attentional Networks in Patients With Cerebral Small Vessel Disease
复制标题
脑小血管病患者注意网络的偏侧性
DOI：
10.3389/fnagi.2020.00021
复制
发表时间：
2020-03-20
影响因子：
4.8
通讯作者：
Wang, Kai
中科院分区：
文献类型：
--
作者：
Cao, Shanshan;Zhang, Jun;Wang, Kai
引言：注意力问题在脑小血管病（CSVD）患者中很常见。正常人脑表现出功能和结构的不对称性。然而，目前尚不清楚CSVD患者是否存在注意偏侧化。目的：本研究采用计算机辅助的偏侧注意网络测验（LANT-R），对CSVD患者的双侧大脑半球的注意功能进行了研究。方法：共纳入58例受试者，其中CSVD组35例，健康对照组23例。所有受试者完成LANT-R范式和神经心理学背景测试。结果：HC组定向网络效率存在左半球偏侧化。然而，CSVD组的偏侧化不明显。此外，组间差异显著（相互作用P = 0.02）。此外，CSVD组受试者在注意功能、记忆功能、信息处理速度和执行功能等几个认知领域的得分低于对照组。结论：CSVD患者注意偏侧化较正常老年人有改变。CSVD患者的注意力下降可能是由于LH对有用信息的选择能力降低所致。
Introduction: Problems with attention are common in patients with cerebral small vessel disease (CSVD). The normal human brain exhibits functional and structural asymmetry. However, it is unknown whether there is lateralization of attention in patients with CSVD. Objective: This study aims to investigate attention separately in both cerebral hemispheres in patients with CSVD using the computer-based Lateralized Attention Network Test—Revised (LANT-R). Methods: The total number of subjects included was 58, which includes the CSVD (N = 35) and healthy control (HC, N = 23) groups. All subjects completed the LANT-R paradigm and neuropsychological background tests. Results: The results indicate that there is an left hemisphere (LH) lateralization in orienting network efficiency in the HC group. However, this lateralization was not apparent in the CSVD group. Furthermore, the difference between groups was significant (interaction P = 0.02). In addition, the scores of subjects in the CSVD group are lower in several cognitive domains, including attention function, memory function, information processing speed, and executive function, compared with the controls. Conclusion: Patients with CSVD change in the lateralization of attention compared with the normal elderly. The decrease in attention in patients with CSVD might be caused by the reduced ability of selecting useful information in the LH.