Topographic differences between normals and schizophrenics: the N120 evoked potential component.
Topographic differences between normals and schizophrenics: the N120 evoked potential component.
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正常人和精神分裂症患者之间的地形差异：N120 诱发电位成分。
DOI：
10.1159/000118232
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发表时间：
1986
影响因子：
3.2
通讯作者：
J. Morihisa
中科院分区：
文献类型：
--
作者：
M. Buchsbaum;S. V. Awsare;H. Holcomb;L. DeLisi;E. Hazlett;W. Carpenter;D. Pickar;J. Morihisa
对20例非药物治疗的慢性精神分裂症患者和24例正常对照进行了诱发电位的地形图测定。每隔1秒，对受试者的右前臂按随机顺序施加四次短暂的电击。从左侧头皮记录诱发电位(EP)。16个左半球导联的脑电数据被用来生成单个受试者的大脑反应的脑电地形图。通过z变换对地图进行归一化处理。然后计算EP活动的组均值图和非配对t检验。正常人在中央前回和中央后回表现出强烈的局部性活动，强度增加导致顶叶反应减弱。精神分裂症患者表现出更多的弥漫性EP活动，且不随强度而变化。正常人和精神分裂症患者在额叶后皮质和顶叶前皮质的四种强度均有显著差异。这与其他人在躯体感觉、视觉和听觉模式中报告的小EPs的发现是一致的。
Topographic differences in evoked potentials were measured in 20 off-medication chronic schizophrenics and 24 normal controls. Four intensities of brief electrical shocks were administered to the subject's right forearm in a random order at 1-second intervals. Evoked potentials (EPs) were recorded from the scalp over the left hemisphere. The EP data from 16 left hemisphere leads were used to generate EP maps of brain response for individual subjects. The maps were normalized by z transformation. Group mean maps of EP activity and unpaired t tests were then computed. Normals showed strongly localized activity in the pre- and postcentral gyri, with increasing intensity resulting in the attenuation of parietal response. Schizophrenics showed more diffuse EP activity which did not vary with intensity. Significant differences between normals and schizophrenics were found for all four intensities in posterior frontal and anterior parietal cortex. This is consistent with the findings of small EPs reported by others in the somatosensory, visual and auditory modalities.