Somatic and behavioral ontogeny in three rat strains: preliminary observations of dopamine-mediated behaviors and brain D-1 receptors.
Somatic and behavioral ontogeny in three rat strains: preliminary observations of dopamine-mediated behaviors and brain D-1 receptors.
复制标题
三种大鼠品系的体细胞和行为个体发育：多巴胺介导的行为和大脑 D-1 受体的初步观察。
DOI：
10.1016/0278-5846(91)90047-5
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发表时间：
1991
影响因子：
5.6
通讯作者：
Diaz,J
中科院分区：
文献类型：
--
作者：
Unis,AS;Petracca,F;Diaz,J
Unis, Alan S.， Frances Petracca和Jamie Diaz：三种大鼠品系的躯体和行为个体发生：多巴胺介导的行为和脑D-1受体的初步观察。掠夺。Neuro-Psychopharmacol。和杂志。精神病学杂志，1991,15(1):129-138。1. 1. 比较了P344、Buff和SD三种大鼠品系（8只/窝）发育里程碑和成熟运动反射的获得情况。2. 2. 在出生后第21天，对运动活动、后腿和中心入口进行开放场地行为评分。3. 3. F344大鼠作为ADHD模型，在获得一系列发育里程碑和体重增加方面是三个品系中最慢的；但在出生后第21天的空地测试中，它们的运动活动和饲养得分处于中等水平。4. 4. 使用D-1特异性配体[3h]-SCH 23390的初步放射自显影数据表明，D-1受体的浓度和分布随年龄变化，与第21天的开放场行为有关。5. 5. F344大鼠表现出发育“不成熟”，这与多动症儿童的情况一致，即与神经和运动成熟相比，躯体发育不成比例地延迟。
Abstract Unis, Alan S., Frances Petracca and Jamie Diaz: Somatic and Behavioral Ontogeny in Three Rat Strains: Preliminary Observations of Dopamine-Mediated Behaviors and Brain D-1 Receptors. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1991, 15 (1): 129–138. 1. 1. The acquisition of developmental milestones and maturational motor reflexes were compared in three rat strains (culled to 8 pups/litter), P344, Buff and SD. 2. 2. Open field behavior on postnatal day 21 was scored for locomotor activity, rears and center entries. 3. 3. F344 rats, which model ADHD, were the slowest of the three strains in acquiring a number of developmental milestones and in gaining weight; but they were intermediate in their scores for locomotor activity and rearing during open field testing at postnatal day 21. 4. 4. Preliminary autoradiographic data using the D-1 specific ligand [3 H]-SCH 23390 are included which suggest that D-1 receptors, which display age-dependent changes in concentration and distribution, are relevant to day 21 open field behavior. 5. 5. F344 rats demonstrate developmental “dysmaturation” which is consistent with that observed in children with ADHD in that somatic growth is disproportionately delayed in comparison to neurological and motor maturation.