Deployed Veterans exhibit distinct respiratory patterns and greater dyspnea during maximal cardiopulmonary exercise: A case-control study.
Deployed Veterans exhibit distinct respiratory patterns and greater dyspnea during maximal cardiopulmonary exercise: A case-control study.
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DOI：
10.1371/journal.pone.0286015
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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西南亚 (SWA) 9/11 后冲突的退伍军人经常出现劳力性呼吸困难和运动不耐受的症状。研究运动期间通气的动态行为可以提供对这些症状的机制洞察。使用最大心肺运动测试（CPET）来实验性地诱发劳累症状，我们的目的是确定部署的退伍军人和未部署的对照组之间潜在的生理差异。已部署 (n = 31) 和未部署 (n = 17) 参与者通过 Bruce 跑步机协议执行最大努力 CPET。间接量热法和感知评定量表用于测量耗氧率 ()、二氧化碳产生率 ()、呼吸频率 (f R)、潮气量 (VT)、每分钟通气量 ()、心率 (HR)、感知用力（RPE；6-20 分值）和呼吸困难（Borg 呼吸困难量表；0-10 分值）。对满足有效努力标准的参与者进行了重复测量方差分析 (RM-ANOVA) 模型（2 组：部署与未部署 X 6 个时间点：0%、20%、40%、60%、80% 和 100%）（部署 = 25；未部署 = 11）。观察到显着的群体效应 (η2partial = 0.26) 和交互效应 (η2partial = 0.10)，因此部署的退伍军人相对于未部署的对照组，表现出 f R 降低和随时间变化更大。呼吸困难评级（η2partial = 0.18）也存在显着的群体效应，显示部署的参与者的值更高。探索性相关分析显示，呼吸困难评级与 fR 之间存在显着相关性，分别为 80%（R2 = 0.34）和 100%（R2 = 0.17），但仅限于已部署的退伍军人。与未部署的对照组相比，部署到 SWA 的退伍军人在最大运动期间表现出 fR 降低和呼吸困难加剧。此外，这些参数之间的关联仅发生在部署的退伍军人中。这些发现支持 SWA 部署与受影响的呼吸健康之间的关联，并强调了 CPET 在退伍军人部署相关呼吸困难的临床评估中的效用。
Exertional dyspnea and exercise intolerance are frequently endorsed in Veterans of post 9/11 conflicts in Southwest Asia (SWA). Studying the dynamic behavior of ventilation during exercise may provide mechanistic insight into these symptoms. Using maximal cardiopulmonary exercise testing (CPET) to experimentally induce exertional symptoms, we aimed to identify potential physiological differences between deployed Veterans and non-deployed controls. Deployed (n = 31) and non-deployed (n = 17) participants performed a maximal effort CPET via the Bruce treadmill protocol. Indirect calorimetry and perceptual rating scales were used to measure rate of oxygen consumption (), rate of carbon dioxide production (), respiratory frequency (f R), tidal volume (VT), minute ventilation (), heart rate (HR), perceived exertion (RPE; 6–20 scale), and dyspnea (Borg Breathlessness Scale; 0–10 scale). A repeated measures analysis of variance (RM-ANOVA) model (2 groups: deployed vs non-deployed X 6 timepoints: 0%, 20%, 40%, 60%, 80%, and 100% ) was conducted for participants meeting valid effort criteria (deployed = 25; non-deployed = 11). Significant group (η2partial = 0.26) and interaction (η2partial = 0.10) effects were observed such that deployed Veterans exhibited reduced f R and a greater change over time relative to non-deployed controls. There was also a significant group effect for dyspnea ratings (η2partial = 0.18) showing higher values in deployed participants. Exploratory correlational analyses revealed significant associations between dyspnea ratings and fR at 80% (R2 = 0.34) and 100% (R2 = 0.17) of , but only in deployed Veterans. Relative to non-deployed controls, Veterans deployed to SWA exhibited reduced fR and greater dyspnea during maximal exercise. Further, associations between these parameters occurred only in deployed Veterans. These findings support an association between SWA deployment and affected respiratory health, and also highlight the utility of CPET in the clinical evaluation of deployment-related dyspnea in Veterans.
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DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
DOI：
10.1164/rccm.201402-0372oc
发表时间：
2014-07-01
影响因子：
24.7
作者：
Morris, Michael J.;Dodson, Darrel W.;Zacher, Lisa L.
通讯作者：
Zacher, Lisa L.
DOI：
10.1249/mss.0000000000001740
发表时间：
2018-12-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Kaminsky, Leonard A.;Harber, Matthew P.;Myers, Jonathan
通讯作者：
Myers, Jonathan
影响因子：
8.3
作者：
Garshick, Eric;Abraham, Joseph H.;Blanc, Paul D.
通讯作者：
Blanc, Paul D.
影响因子：
24.3
作者：
Miller, MR;Hankinson, J;Wanger, J
通讯作者：
Wanger, J