Off limits - Integrins holding boundaries in somitogenesis
Off limits - Integrins holding boundaries in somitogenesis
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DOI：
10.1016/j.tcb.2005.07.008
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发表时间：
2005-09-01
影响因子：
19
通讯作者：
Jiang, YJ
中科院分区：
文献类型：
--
作者：
Chong, SW;Jiang, YJ
在脊椎动物发育过程中，边界对于划分重复结构（如体）至关重要。最近的两篇文章描述了整合素α 5及其配体纤维连接蛋白1在斑马鱼前体间边界形成中的作用，并将它们与Notch和ephf - ephrin通路在体间边界细胞上皮化中的作用联系起来。与这些通路一起，整合素5和纤维连接蛋白1协调了体小体和后来的肌小体边界的有序形成。这些研究揭示了周期性分割机制下游的组成部分-体细胞发生中的“分割时钟”。
Borders are essential for demarcating repeated structures such as somites during vertebrate development. Two recent articles describe roles for Integrin alpha 5 and its ligand Fibronectin1 in zebrafish anterior intersomitic boundary formation and link them to Notch and Eph-Ephrin pathways in epithelialization of somite boundary cells. Together with these pathways, Integrin alpha 5 and Fibronectin1 orchestrate the orderly formation of somite and later myotome borders. These studies shed light on components downstream of the periodic segmentation mechanism - the 'segmentation clock' in somitogenesis.