Chiral Surfactant-Type Catalyst for Asymmetric Reduction of Aliphatic Ketones in Water
Chiral Surfactant-Type Catalyst for Asymmetric Reduction of Aliphatic Ketones in Water
复制标题
用于水中脂肪酮不对称还原的手性表面活性剂型催化剂
DOI：
10.1021/ja308357y
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发表时间：
2012-11-14
影响因子：
15
通讯作者：
Deng, Jingen
中科院分区：
文献类型：
--
作者：
Li, Jiahong;Tang, Yuanfu;Deng, Jingen
开发了一种新型手性表面活性剂型催化剂。通过催化剂本身的缔合，在水中形成胶束，这通过 TEM 分析得到证实。手性金属胶束催化剂催化的脂肪酮不对称转移氢化反应具有良好的转化率和显着的立体选择性（高达 95% ee）。金属胶束中金属催化中心和核心疏水性微环境之间的协同效应导致了高对映选择性。
A novel chiral surfactant-type catalyst is developed. Micelles formed in water by association of the catalysts themselves, and this was confirmed by TEM analyses. Asymmetric transfer hydrogenation of aliphatic ketones catalyzed by the chiral metallomicellar catalyst gave good to excellent conversions and remarkable stereoselectivities (up to 95% ee). Synergistic effects between the metal catalyzed center and the hydrophobic microenvironment of the core in the metallomicelle led to high enantioselectivities.