Further Proof that the Spinal Cord and Not the Brain, Mediates the Immobility Produced by Inhaled Anesthetics
Further Proof that the Spinal Cord and Not the Brain, Mediates the Immobility Produced by Inhaled Anesthetics
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进一步证明是脊髓而不是大脑调节吸入麻醉剂产生的不动
DOI：
10.1097/aln.0b013e3181974bfd
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发表时间：
2009-03-01
期刊：
影响因子：
8.8
通讯作者：
Liu, Jin
中科院分区：
文献类型：
--
作者：
Yang, Jing;Chai, Yun-Fei;Liu, Jin
背景：先前的研究表明，脊髓（可能对大脑有较小的贡献）介导吸入麻醉剂在面对有害刺激时产生不动的能力。这些研究的意义可能受到与其实验方法（例如心肺旁路或脊髓横断）相关的创伤的限制。本研究避免了这种创伤。方法：30只山羊通过主动脉的初始部分（动脉组；优先将异氟烷输送到脊髓）或耳静脉（静脉组；将异氟烷平等地输送到脊髓和大脑）接受乳化异氟醚。作者确定了异氟烷的最小分压（50% 暴露于有害刺激的山羊产生不动所需的血液中的异氟烷分压）。结果：对于静脉组，颈动脉血与股动脉血的最小分压（9.56 +/- 1.86 mmHg 与 9.68 +/- 1.90 mmHg）没有差异。对于动脉组，颈动脉血的最小分压是股动脉血的一半（5.35 +/- 1.45 mmHg vs. 10.97 +/- 3.04 mmHg，P < 0.05）。正如这些数据显示的那样，动脉组与静脉组的股动脉血中的最小分压没有差异。结论：在这个新颖且创伤最小的模型中，传递到脊髓的麻醉分压控制着对有害刺激的反应的运动抑制。结果表明，脊髓是不动的主要调节者，而大脑几乎没有发挥作用。
Background: Previous investigations indicate that die spinal cord, perhaps with a minor cerebral contribution, mediates the capacity of inhaled anesthetics to produce immobility in the face of noxious stimulation. The implications of these investigations may be limited by the trauma associated with their experimental methods (e.g., cardiopulmonary bypass or transection of the spinal cord). The present study avoided such trauma.Methods: Thirty goats received emulsified isoflurane via either the initial section of the aorta (arterial group; preferential isoflurane delivery to the spinal cord) or an ear vein (venous group; equal delivery of isoflurane to the cord and brain). The authors determined the minimum partial pressure of isoflurane (the isoflurane partial pressure in the blood required to produce Immobility in 50% of the goats exposed to a noxious stimulus).Results: For the venous group, the minimum partial pressure in carotid versus femoral arterial blood (9.56 +/- 1.86 mmHg vs. 9.68 +/- 1.90 mmHg) did not differ. For the arterial group, the minimum partial pressure in carotid arterial blood was half that in femoral arterial blood (5.35 +/- 1.45 mmHg vs. 10.97 +/- 3.04 mmHg, P < 0.05). As these data show, the minimum partial pressure In femoral arterial blood did not differ for the arterial group versus the venous group.Conclusions: In this novel and minimally traumatic model, the anesthetic partial pressure delivered to the spinal cord governed the suppression of movement in response to noxious stimulation. The results indicate that the spinal cord is the primary mediator of immobility and that the brain plays little or no role.