Role of exosomal small RNA in prostate cancer metastasis.
Role of exosomal small RNA in prostate cancer metastasis.
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外泌体小RNA在前列腺癌转移中的作用
DOI：
10.2147/cmar.s170610
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发表时间：
2018
影响因子：
3.3
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Zhan F;Shen J;Wang R;Wang L;Dai Y;Zhang Y;Huang X
前列腺癌（PCa）是全球男性中第二常见的癌症。当疾病转移时，存在有限的治疗策略，并且转移性疾病难以预测。最近，有证据表明，小RNA在患者体液中是可检测的，并且外泌体小RNA异位表达与人PCa的发展、进展和转移相关;然而，小RNA在PCa中的作用仅部分被理解。本文就循环外泌体小RNA及其在前列腺癌中的应用，特别是在转移性疾病中的研究现状进行综述。外泌体小RNA可作为前列腺癌早期诊断、微转移检测和预后判断的潜在生物标志物。
Prostate cancer (PCa) is the second most common cancer in men worldwide. When the disease becomes metastatic, limited treatment strategies exist, and metastatic disease prognoses are difficult to predict. Recently, evidence has emerged, which indicates that small RNAs are detectable in patient fluids, and exosomal small RNA ectopic expression is correlated with the development, progression, and metastasis of human PCa; however, the role of small RNAs in PCa is only partially understood. In this review, we discuss the research status regarding circulating exosomal small RNAs and applications using these small RNAs in PCa particularly looking at metastatic disease. Exosomal small RNAs could be used as potential biomarkers for the early diagnosis, micrometastasis detection, and prognosis of PCa.