Damaged utricular function clarified by oVEMP in patients with benign paroxysmal positional vertigo
Damaged utricular function clarified by oVEMP in patients with benign paroxysmal positional vertigo
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DOI：
10.3109/00016489.2012.720030
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发表时间：
2013-02-01
影响因子：
1.4
通讯作者：
Murofushi, Toshihisa
中科院分区：
文献类型：
--
作者：
Nakahara, Haruka;Yoshimura, Eriko;Murofushi, Toshihisa
结论：眼前庭诱发肌源性电位（oVEMP）的结果支持后管良性阵发性位置性眩晕（pBPPV）患者的椭圆囊功能障碍。目的：评价 pBPPV 患者的椭圆囊和囊泡功能。方法：本研究重点关注 12 名经 Dix-Hallpike 操作明确诊断为 pBPPV 且表现出典型眼球震颤的患者和 12 名对照者。在这些受试者中，测量了空气传导 500 Hz 突发音调 (125 dB SPL) 的 oVEMP 和 cVEMP。患者还接受了热量测试。结果：与对照组相比，更多的pBPPV患者在受患侧刺激后出现oVEMPs异常反应，而cVEMPs结果显示pBPPV患者和对照组之间没有显着差异。 pBPPV 患者患侧 oVEMP 异常结果的比例高于 cVEMP 和热量测试结果。任何测试之间都没有显着关联。这些发现支持了这样的可能性：oVEMP 反映了 pBPPV 的特定异常情况，即 pBPPV 患者的荨麻疹功能严重受损。
Conclusion: Utricular dysfunction in patients with posterior canal benign paroxysmal positional vertigo (pBPPV) was supported by findings for ocular vestibular evoked myogenic potential (oVEMP). Objective: To evaluate the utricular and saccular function in patients with pBPPV. Methods: This study focused on 12 patients definitively diagnosed with pBPPV showing typical nystagmus by Dix-Hallpike maneuver and 12 controls. In these subjects, oVEMPs and cVEMPs to air-conducted 500 Hz tone burst (125 dB SPL) were measured. The patients also underwent caloric tests. Results: More of the patients with pBPPV showed abnormal responses in oVEMPs by stimulation on their affected side than the controls, while the results of cVEMPs showed no significant differences between pBPPV patients and controls. The abnormal results for oVEMPs on the affected side showed a higher percentage than those for cVEMPs and caloric tests in pBPPV patients. There was no significant association between any of the tests. These findings support the possibility that oVEMP reflects the specific abnormal condition in pBPPV, i.e. that the urticular function in pBPPV patients was highly damaged.