A chronic high‐fat diet does not exacerbate muscle atrophy in fast‐twitch skeletal muscle of aged mice
A chronic high‐fat diet does not exacerbate muscle atrophy in fast‐twitch skeletal muscle of aged mice
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DOI：
10.1113/ep091106
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发表时间：
2023-04
影响因子：
2.7
通讯作者：
Tsutomu Tagawa;Hiroaki Eshima;Saori Kakehi;R. Kawamori;H. Watada;Y. Tamura
中科院分区：
文献类型：
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作者：
Tsutomu Tagawa;Hiroaki Eshima;Saori Kakehi;R. Kawamori;H. Watada;Y. Tamura
这项研究的中心问题是什么？衰老导致骨骼肌质量损失，但肥胖对衰老相关肌肉萎缩的影响尚不清楚。在这项研究中，我们的目的是证明肥胖对快速收缩骨骼肌衰老的具体影响。主要发现及其重要性是什么？我们的研究结果表明，长期摄入高脂饮食诱导的肥胖不会加剧老年小鼠快缩骨骼肌的肌肉萎缩，表明本研究为肌肉减少性肥胖的骨骼肌提供了形态学特征。
What is the central question of this study? Ageing leads to a loss of mass in skeletal muscle, but the effect of obesity on ageing‐related muscle wasting is unclear. In this study, we aimed to demonstrate the specific effect of obesity on fast‐twitch skeletal muscle in ageing. What is the main finding and its importance? Our findings show that the obesity induced by long‐term ingestion of a high‐fat diet does not aggravate muscle wasting in fast‐twitch skeletal muscle of aged mice, indicating that the present study provides morphological characteristics for skeletal muscle of sarcopenic obesity.