Age and gender specific prevalence of HTLV-1
Age and gender specific prevalence of HTLV-1
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DOI：
10.1016/j.jcv.2009.03.012
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发表时间：
2009-06-01
影响因子：
8.8
通讯作者：
Karukaya, Shigeru
中科院分区：
文献类型：
--
作者：
Eshima, Nobuoki;Iwata, Osuke;Karukaya, Shigeru
背景资料：尽管成人T细胞白血病（ATL）在男性中的发病率较高，但人类T细胞白血病病毒1型（HTLV-1）的血清阳性率主要为女性。如果HTLV-1的母婴传播在男婴中比女婴中更常见，那么男性接触病毒的时间更长可能解释了ATL发病率更高的矛盾。目的：检验HTLV-1的血清阳性率在青春期以男性为主的假设。在HTLV-1高流行地区的一个地区血库中，对272，043份血液样本中HTLV-1抗体的存在进行了评估。与男性相比，女性供体的整个群体具有显著更高的血清阳性率（分别为2.05%和1.80%，p < 0.0001）。然而，与男性供体相比，最年轻亚组（16-19岁，p = 0.0011）的女性供体携带率较低;接下来的两个年龄亚组（20-29岁和30-39岁）相似;最后两个年龄亚组（40-49岁和50-64岁以上，p均< 0.0001）显著较高。在一般情况下，年龄较大的亚组导致更高的血清阳性率在两个genders.Conclusions：HTLV-I感染是更常见的男性，直到20岁以后，当男性到女性的性传播成为可能。这表明母婴传播在男性中更为常见。(C)2009 Elsevier B. V.保留所有权利。
Background: The seroprevalence of Human T-cell Leukemia Virus Type 1 (HTLV-1) is female predominant despite the higher incidence of Adult T-cell Leukemia (ATL) in males. If the mother-to-child transmission of HTLV-1 is more common for male infants than in female infants, longer exposure to the virus for males may explain the paradoxically higher incidence of ATL.Objectives: To test the hypothesis that the seroprevalence of HTLV-1 is male predominant during adolescence.Study design: The presence of HTLV-1 antibody in 272,043 blood samples donated to a regional blood bank in an HTLV-1 high-endemic region was assessed.Results: The entire population of female donors had a significantly higher seroprevalence compared to males (2.05% and 1.80%, respectively, p < 0.0001). However, compared with male donors, the carrier rate for female donors was lower for the youngest subgroup (16-19 years, p = 0.0011); was similar for the next two age subgroups (20-29 years and 30-39 years); and was significantly higher for the last two age subgroups (40-49 years and over 50-64 years, both p < 0.0001). In general, older age subgroups led to higher seroprevalence in both genders.Conclusions: HTLV-I infection is more common for males until after age 20, when male to female sexual transmission becomes likely. This suggests that mother-to-child transmission is more common for males. (C) 2009 Elsevier B.V. All rights reserved.