The Interactive Fly: gene networks, development and the Internet
The Interactive Fly: gene networks, development and the Internet
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DOI：
10.1016/s0168-9525(99)01775-8
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发表时间：
1999-08-01
影响因子：
11.4
通讯作者：
Brody, T
中科院分区：
文献类型：
--
作者：
Brody, T
TIG 1999年8月，第15卷，第8期，334，尚未在果蝇中鉴定，交叉引用这些相互作用也超出了IF的范围;（4）生物学概述适合果蝇生物学，忽略了许多基因在其他生物体中具有独特功能的事实。其他几个“互动”项目可能被证明具有长期实际用途。以非洲爪蟾为模型，广泛整合来自小鼠的信息，一个“互动原肠胚形成”项目可能对生物界和学生有用。在非洲爪蟾和小鼠的原肠胚形成过程中，已知有超过100个基因表达，脊椎动物原肠胚形成过程中基因激活的层次结构与果蝇完全不同。一个单一的策展人将足以发展一个互动原肠胚形成项目。其他建议的交互式项目包括“交互式细胞凋亡”，以记录细胞凋亡中的基因相互作用，以及“交互式细胞周期”，以描绘细胞周期调控的复杂性。
TIG August 1999, volume 15, No. 8 334 not yet identified in the fly and crossreferencing these interactions is also beyond the scope of the IF; and (4) the biological overviews are geared to Drosophila biology, omitting the fact that many genes have assumed unique functions in other organisms. Several other ‘interactive’projects could prove to be of long-term practical use. Using Xenopus as a model, with extensive integration of information from the mouse, an ‘interactive gastrulation’project could prove useful to the biological community and students. There are well over 100 genes known to be expressed in Xenopus and in the mouse during gastrulation, and the hierarchy of gene activation during gastrulation in vertebrates is completely different from that in Drosophila. A single curator would be sufficient for the development of an interactive gastrulation project. Other suggested interactive projects include ‘interactive apoptosis’ to document the gene interactions in apoptosis, and an ‘interactive cell cycle’to portray the complexities of cell-cycle regulation.