Clinical course of primary Sjögren's syndrome: salivary, oral, and serologic aspects.
Clinical course of primary Sjögren's syndrome: salivary, oral, and serologic aspects.
复制标题
原发性干燥综合征的临床过程：唾液、口腔和血清学方面。
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
P. Fox
中科院分区：
文献类型：
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作者：
G. Gannot;H. Lancaster;P. Fox
目标
评估原发性干燥综合征 (SS) 的症状和体征、唾液功能、血清学活性和疾病进展的变化。
方法
对 80 名在临床就诊并按规定标准诊断为原发性 SS 的患者的治疗记录进行了审查。 49 名患者接受了至少两次评估，评估间隔至少为 5 年（平均 7 年）。获得每个主要唾液腺的唾液流速和实验室值。我们进行了结构化访谈，询问有关原发性 SS 体征和症状的问题，并进行了体检。另外 26 名患者通过邮寄方式完成了后续调查问卷，并获取了他们当前的医疗记录以供审查。对于该组，随访期平均为初次评估后 10 年。五名患者死亡。
结果
两次就诊的患者的唾液测量值和血清学值均表现出相对稳定性。 75 名幸存患者的口腔和眼睛干燥的主观干燥症状仍然很突出。很少有人会患上另一种结缔组织病，从而演变成继发性 SS。 80名患者中，随访期间发现6例B细胞淋巴瘤。
结论
虽然原发性 SS 不是一种良性病症，但它是一种进展非常缓慢的疾病，除了淋巴瘤的高发病率外，唾液功能、疾病活动的全身标志物或症状的显着变化不会迅速恶化。
OBJECTIVE
To assess changes in symptoms and signs, salivary function, serologic activity, and disease progression in primary Sjogren's syndrome (SS).
METHODS
Treatment records on 80 patients seen in clinic and diagnosed with primary SS by defined criteria were reviewed. Forty-nine patients were evaluated at least twice a minimum of 5 years (mean 7 years) apart. Salivary flow rates from each of the major salivary glands and laboratory values were obtained. A structured interview with questions pertaining to signs and symptoms of primary SS was given and a physical examination was performed. An additional 26 patients completed a followup questionnaire by mail and their current medical records were obtained for review. For this group, the followup period was a mean of 10 years after their initial evaluation. Five patients were deceased.
RESULTS
The patients seen twice showed relative stability in their salivary measurements and in their serologic values. The subjective sicca symptoms of oral and ocular dryness among the 75 surviving patients remained prominent. Very few individuals developed another connective tissue disease, therefore evolving into secondary SS. Among the 80 patients, 6 cases of B cell lymphoma were recognized during the followup period.
CONCLUSION
Although it is not a benign condition, primary SS is a very slowly progressing disease without rapid deterioration in salivary function, systemic markers of disease activity, or dramatic changes in symptoms, with the exception of a high incidence of lymphoma.