Quantitative Photoacoustic Image Reconstruction using Fluence Dependent Chromophores.
Quantitative Photoacoustic Image Reconstruction using Fluence Dependent Chromophores.
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DOI：
10.1364/boe.1.000201
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发表时间：
2010-07-16
影响因子：
3.4
通讯作者：
Beard PC
中科院分区：
文献类型：
--
作者：
Cox BT;Laufer JG;Beard PC
在生物医学光声成像中，图像与吸收的光能量密度成正比，而不是与光吸收成正比，这使得仅通过光声测量很难获得显示特定吸收生色团浓度的定量准确图像。这里表明，可以根据在增加的照明强度下获得的光声图像来估计其吸收在阈值光通量以上变为零的发色团的空间变化浓度。该技术提供了基于模型的多波长定量光声成像方法的替代方法，以及光声分子和功能成像的新方法。
In biomedical photoacoustic imaging the images are proportional to the absorbed optical energy density, and not the optical absorption, which makes it difficult to obtain a quantitatively accurate image showing the concentration of a particular absorbing chromophore from photoacoustic measurements alone. Here it is shown that the spatially varying concentration of a chromophore whose absorption becomes zero above a threshold light fluence can be estimated from photoacoustic images obtained at increasing illumination strengths. This technique provides an alternative to model-based multiwavelength approaches to quantitative photoacoustic imaging, and a new approach to photoacoustic molecular and functional imaging.