A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis.
A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis.
复制标题
多发性硬化症模型中髓磷脂特异性CD8（+）T细胞的致病作用。
DOI：
10.1084/jem.194.5.669
复制
发表时间：
2001-09-03
影响因子：
15.3
通讯作者：
Goverman, J
中科院分区：
文献类型：
--
作者：
Huseby, E S;Liggitt, D;Brabb, T;Schnabel, B;Ohlen, C;Goverman, J
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4+ and CD8+ T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4+ myelin-specific T cells. The role of CD8+ myelin-specific T cells in mediating EAE or MS has not been described previously. Here, we demonstrate that myelin-specific CD8+ T cells induce severe CNS autoimmunity in mice. The pathology and clinical symptoms in CD8+ T cell–mediated CNS autoimmunity demonstrate similarities to MS not seen in myelin-specific CD4+ T cell–mediated EAE. These data suggest that myelin-specific CD8+ T cells could function as effector cells in the pathogenesis of MS.
